Gene Symbol | MARC1 |
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Entrez Gene | 64757 |
Alt Symbol | MOSC1 |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial amidoxime reducing component 1 |
Other Description | MOCO sulphurase C-terminal domain containing 1|MOSC domain-containing protein 1, mitochondrial|mitochondrial amidoxime-reducing component 1|moco sulfurase C-terminal domain-containing protein 1|molybdenum cofactor sulfurase C-terminal domain-containing protein 1 |
Swissprots | Q9H6C7 Q5VT66 B2D078 A8K447 Q96FN8 Q5VVS9 Q5VVT0 Q8N9P5 Q5VVT1 |
Accessions | ACB21046 EAW93291 Q5VT66 AK000035 AK026043 BAB15333 AK092439 AK094105 BAC04286 AK225416 AK290812 BAF83501 BC010619 AAH10619 CA439234 CB048738 DA878171 XM_011509900 XP_011508202 XM_011509901 XP_011508203 XM_011509902 XP_011508204 XM_011509903 XP_011508205 XM_011509904 XP_011508206 XR_921908 NM_022746 NP_073583 |
Function | As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. {ECO:0000269|PubMed:19053771}. |
Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:23086957}; Single-pass type II membrane protein {ECO:0000269|PubMed:23086957}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. |
MOSC1 CRISPR/Cas9 KO Plasmid (h) - sc-413027 from Santa Cruz Biotechnology
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MOSC1 HDR Plasmid (h) - sc-413027-HDR from Santa Cruz Biotechnology
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MOSC1 Double Nickase Plasmid (h) - sc-413027-NIC from Santa Cruz Biotechnology
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MOSC1 Double Nickase Plasmid (h2) - sc-413027-NIC-2 from Santa Cruz Biotechnology
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MOSC1 CRISPR Activation Plasmid (h) - sc-413027-ACT from Santa Cruz Biotechnology
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MOSC1 CRISPR Activation Plasmid (h2) - sc-413027-ACT-2 from Santa Cruz Biotechnology
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MOSC1 Lentiviral Activation Particles (h) - sc-413027-LAC from Santa Cruz Biotechnology
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MOSC1 Lentiviral Activation Particles (h2) - sc-413027-LAC-2 from Santa Cruz Biotechnology
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MOSC1 siRNA (h) - sc-88493 from Santa Cruz Biotechnology
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MOSC1 shRNA Plasmid (h) - sc-88493-SH from Santa Cruz Biotechnology
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MOSC1 shRNA (h) Lentiviral Particles - sc-88493-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14482 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14482 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12458 from Sigma-Aldrich
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MARC1 siRNA (Human) - CRJ2067 from Cohesion Biosciences
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shRNA set against Human MOSC1 (NM_022746.3) - SHH343656 from Creative biogene
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MARC1 shRNA Plasmid (Human) - CHJ2067 from Cohesion Biosciences
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MARC1 miRNA 3'UTR clone - MiUTR3H-13141 from Creative biogene
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