HCFC1

Gene Symbol HCFC1
Entrez Gene 3054
Alt Symbol CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF
Species Human
Gene Type protein-coding
Description host cell factor C1
Other Description VP16-accessory protein|host cell factor 1|protein phosphatase 1, regulatory subunit 89
Swissprots Q6P4G5 P51610
Accessions AAB27583 CAA55790 EAW72767 EAW72768 EAW72769 P51610 BC010606 BC019887 AAH19887 BC030560 AAH30560 BC063435 AAH63435 DQ655939 GU014839 ACX32326 L20010 XM_006724815 XP_006724878 XM_006724816 XP_006724879 XM_011531144 XP_011529446 XM_011531145 XP_011529447 XM_011531146 XP_011529448 XM_011531147 XP_011529449 XM_011531148 XP_011529450 XM_011531149 XP_011529451 XM_011531150 XP_011529452 NM_005334 NP_005325
Function Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|Pub
Subcellular Location Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER.
Tissue Specificity Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269|PubMed:9389645}.
Top Pathways Herpes simplex infection

HCF1 (H-8) - sc-390950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HCF1 (H-8): sc-390950. Western blot analysis of HCF1 expression in Raji (A) and K-562 (B) whole cell lysates.

HCF1 (H-46) - sc-367388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

HCF1 (I-20) - sc-13427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCF1 (I-20): sc-13427. Western blot analysis of HCF1 expression in Jurkat (A), K-562 (B), Raji (C) and Daudi (D) whole cell lysates.

HCF1 (N-16) - sc-13426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCF1 (N-16): sc-13426. Western blot analysis of HCF1 expression in Hep G2 (A) and KNRK (B) whole cell lysates.

HCF1 (D-20) - sc-13429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCF1 (D-20): sc-13429. Western blot analysis of HCF1 expression in Jurkat (A), K-562 (B), Raji (C) and Daudi (D) whole cell lysates.

HCF1/2 (C-19) - sc-13432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCF1/2 (C-19): sc-13432. Western blot analysis of HCF1/2 expression in IMR-32 whole cell lysate (A) and IMR-32 nuclear extract (B).

HCF1/2 (P-16) - sc-13430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HCF-1 / Host Cell Factor C1 antibody - N-terminal - ab137618 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HCF-1 / Host Cell Factor C1 antibody - N-terminal (ab137618) at 1/500 dilution + Mouse brain whole cell lysate at 50 µg

Anti-HCF-1 / Host Cell Factor C1 antibody - N-terminal - ab177872 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HCF-1 / Host Cell Factor C1 antibody - N-terminal (ab177872) at 1 µg/ml + Human uterus tumor lysate at 10 µg

Anti-HCF-1 / Host Cell Factor C1 antibody - N-terminal - ab139372 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human tonsil tissue labelling HCF-1 / Host Cell Factor C1 with ab139372 at 10 &microg/ml.

Anti-HCF-1 / Host Cell Factor C1 antibody - ab110896 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110896 at 1/50 dilution staining HCF-1 / Host Cell Factor C1 in paraffin-embedded Human Breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-HCF-1 / Host Cell Factor C1 antibody - ab94631 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCF1 / HCFC1 Antibody (aa1700-1750) - LS-C288193 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCF1 / HCFC1 Antibody (aa1985-2035) - LS-C288195 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCF1 / HCFC1 Antibody (aa91-140) - LS-C31623 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-HCF1 / HCFC1 Antibody (C-Terminus) - LS-C110294 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HCFC1 / HCF-1 antibody LS-C110294 Western blot of Fetal Stomach lysate.

Anti-HCF1 / HCFC1 Antibody (N-Terminus) - LS-C186676 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Uterus Tumor. HCFC1 antibody dilution 1.0 ug/ml.

Anti-HCF1 / HCFC1 Antibody - LS-C331718 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human rectal cancer using HCFC1 antibody at dilution of 1:200 (x400 lens)

Anti-HCF1 / HCFC1 Antibody - LS-C193033 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of HEK-293 cell lines, using HCFC1 antibody.

Anti-HCF1 / HCFC1 Antibody (aa131-180) IHC-plus™ - LS-B7675 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HCFC1 / HCF-1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7675 concentration 10 ug/ml.

Host Cell Factor 1/HCFC1 Antibody - NB100-68210 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HCFC1 Antibody [NB100-68210] - Detection of Human HCF1 on HeLa whole cell lysate using 100-68210. HCF1 was also immunoprecipitated by rabbit anti-HCF1 antibody NB100-68209.

Host Cell Factor 1/HCFC1 Antibody - NB100-68209 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Host Cell Factor 1/HCFC1 Antibody [NB100-68209] - Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-HCF1 antibody NB100-68209 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. HCF1 was also immunoprecipitated by rabbit anti-HCF1 antibody NB100-68210, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).

Host Cell Factor 1/HCFC1 Antibody - NBP2-16786 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HCFC1 Antibody [NBP2-16786] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 5% SDS PAGE gel, diluted at 1:500.

Host Cell Factor 1/HCFC1 Antibody [Unconjugated] - AF6254 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and Daudi human Burkitt's lymphoma cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human Host Cell Factor 1/HCFC1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6254) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). Specific bands were detected for Host Cell Factor 1/HCFC1 at approximately 300 kDa (as indicated) and proteolytic fragments of Host Cell Factor 1/HCFC1 at approximately 100 to 175 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

HCF-1 Polyclonal Antibody - bs-7803R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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