| Gene Symbol | HMGCR |
|---|---|
| Entrez Gene | 3156 |
| Alt Symbol | LDLCQ3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-hydroxy-3-methylglutaryl-CoA reductase |
| Other Description | 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|3-hydroxy-3-methylglutaryl-Coenzyme A reductase|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase |
| Swissprots | B7Z3Y9 Q8N190 P04035 |
| Accessions | AAG21343 AAP72015 CAZ64465 EAW95754 EAW95755 EAW95756 P04035 AA648735 AK292892 BAF85581 AK296499 BAH12375 AK299655 BAG61573 AK312437 BAG35346 AY429541 AY429542 AY429543 BC024180 BC033692 AAH33692 CN278665 DQ890855 ABM81781 DQ894009 ABM84935 M11058 AAA52679 M62627 M62633 XM_011543357 XP_011541659 XM_011543358 XP_011541660 XM_011543359 XP_011541661 NM_000859 NP_000850 NM_001130996 NP_001124468 |
| Function | Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Top Pathways | Terpenoid backbone biosynthesis, Bile secretion, AMPK signaling pathway |