HMGCR

Gene Symbol HMGCR
Entrez Gene 3156
Alt Symbol LDLCQ3
Species Human
Gene Type protein-coding
Description 3-hydroxy-3-methylglutaryl-CoA reductase
Other Description 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|3-hydroxy-3-methylglutaryl-Coenzyme A reductase|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase
Swissprots B7Z3Y9 Q8N190 P04035
Accessions AAG21343 AAP72015 CAZ64465 EAW95754 EAW95755 EAW95756 P04035 AA648735 AK292892 BAF85581 AK296499 BAH12375 AK299655 BAG61573 AK312437 BAG35346 AY429541 AY429542 AY429543 BC024180 BC033692 AAH33692 CN278665 DQ890855 ABM81781 DQ894009 ABM84935 M11058 AAA52679 M62627 M62633 XM_011543357 XP_011541659 XM_011543358 XP_011541660 XM_011543359 XP_011541661 NM_000859 NP_000850 NM_001130996 NP_001124468
Function Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Top Pathways Terpenoid backbone biosynthesis, Bile secretion, AMPK signaling pathway

HMGCR (C-1) - sc-271595 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HMGCR (C-1): sc-271595. Western blot analysis of HMGCR expression in non-transfected: sc-117752 (A) and mouse HMGCR transfected: sc-120842 (B) 293T whole cell lysates.

HMGCR (C-18) - sc-27578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HMGCR (C-18): sc-27578. Western blot analysis of HMGCR membrane-bound glycoprotein expression and HMGCR C-terminal cleavage product expression in Hep G2 (A) and TT (B) whole cell lysates.

HMGCR (H-300) - sc-33827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HMGCR (H-300): sc-33827. Western blot analysis of HMGCR expression in non-transfected: sc-117752 (A) and mouse HMGCR transfected: sc-120842 (B) 293T whole cell lysates.

HMGCR (K-15) - sc-27580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HMGCR antibody - ab99383 from Abcam

Prices $376.00
Sizes 125 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HMGCR antibody (ab99383) at 1/1000 dilutionLane 1 : UT2 cell lysateLane 2 : UT2 FL-HMGCR cell lysateLysates/proteins at 60 µg per lane.

Anti-HMGCR antibody [EPR1685(N)] - ab174830 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1685(N)
All lanes : Anti-HMGCR antibody [EPR1685(N)] (ab174830) at 1/300 dilution (unpurified)Lane 1 : Jurkat cell lysateLane 2 : TT cell lysateLysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-HMG-CoA Reductase / HMGCR Antibody (aa295-308) - LS-C112813 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C147064 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C310626 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C285529 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (aa571-855) - LS-C311702 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (Biotin) - LS-C317112 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (FITC) - LS-C318761 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C192794 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of various cell lines, using HMGCR antibody.

Anti-HMG-CoA Reductase / HMGCR Antibody (HRP) - LS-C318764 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (C-Terminus) - LS-C345433 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of HMDH Antibody with human Fetal Lung lysate.

Anti-HMG-CoA Reductase / HMGCR Antibody (C-Terminus) - LS-C345666 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of HMDH Antibody with human MCF7 Whole Cell lysate.

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C331599 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney using IL23R antibody at dilution of 1:200 (x400 lens)

HMG-CoA Reductase/HMGCR Antibody - 46580002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELISA: HMGCR Antibody [46580002]

HMG-CoA Reductase/HMGCR Antibody - NBP1-91996 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: HMGCR Antibody [NBP1-91996] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

HMG-CoA Reductase/HMGCR Antibody - NBP1-36961 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

HMGCR Antibody - H00003156-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HMGCR(Ser872) Polyclonal Antibody - bs-4063R from Bioss

Prices $299.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat liver tissue labeled with Anti-phospho-HMGCR(Ser872) Polyclonal Antibody, Unconjugated (bs-4063R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

HMGCR Polyclonal Antibody - bs-5068R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-HMGCR Polyclonal Antibody, Unconjugated (bs-5068R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-HMGCR antibody produced in rabbit - SAB4200528 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Mevastatin-treated HepG2 cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton X-100. Fixed cells were stained with 1 μg/mL Rabbit Anti-HMGCR (<B>Cat. No. SAB4200528</B>). The antibody was developed using Goat Anti-Rabbit IgG, Cy3 conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.
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