PVR

Gene Symbol	PVR
Entrez Gene	5817
Alt Symbol	CD155, HVED, NECL5, Necl-5, PVS, TAGE4
Species	Human
Gene Type	protein-coding
Description	poliovirus receptor
Other Description	nectin-like protein 5
Swissprots	Q96BJ1 P15151 Q15267 B4DTS9 P15152 Q15268
Accessions	AAF69803 CAA45478 CAA45479 CAA45480 CBX51265 EAW57284 EAW57285 EAW57286 P15151 AI374885 AK025949 AK094177 BAG52836 AK098812 AK290946 BAF83635 AK300349 BAG62091 BC015542 AAH15542 BE838104 CA416069 DA849917 DC400059 DQ890969 ABM81895 DQ894143 ABM85069 M24406 AAA36462 M24407 AAA36461 XM_005259120 XP_005259177 NM_001135768 NP_001129240 NM_001135769 NP_001129241 NM_001135770 NP_001129242 NM_006505 NP_006496
Function	Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing
Subcellular Location	Isoform Beta: Secreted.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Poliovirus Receptor protein fragment - ab155723 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Poliovirus Receptor full length protein - ab152642 from Abcam Category Protein Source Wheat germ Species Human

Human Poliovirus Receptor protein fragment - ab152643 from Abcam Category Protein Source Wheat germ Species Human

Human Poliovirus Receptor protein fragment - ab152038 from Abcam Category Protein Source HEK 293 cells Species Human

CD155/PVR Partial Recombinant Protein - H00005817-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CD155/PVR Recombinant Protein - H00005817-P01 from Novus Biologicals Category Protein

CD155/PVR Recombinant Protein - H00005817-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Human CD155/PVR - 2530-CD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly27-Asn343, with a C-terminal 6-His tag

Recombinant Human CD155/PVR, CF - 2530-CD-050/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly27-Asn343, with a C-terminal 6-His tag

Human Poliovirus Receptor Protein - abx068619 from Abbexa Category Protein Source E.coli Species Human

CD155 / PVR - H00005817-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD155 / PVR - H00005817-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD155 / PVR - H00005817-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD155 / PVR - H00005817-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD155 / PVR - H00005817-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Poliovirus Receptor, PVR, Human, Recombinant - 19-C622 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

PVR Recombinant Protein - 96-116 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

Recombinant Human PVR Protein - BP001763-C622 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human PVR, Fc tagged - PVR-620H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PVR, None tagged - PVR-621H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PVR, His tagged - PVR-3141H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PVR, His-tagged - PVR-308H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Human Poliovirus Receptor - PVR-4761H from Creative Biomart Category Protein Source Recombinant human CD155/PVR Gly27-Asn343 (Accession AAH15542) fused with a C-terminal 6-His tag was produced in human HEK293 cells. Species Human

Human CD155 Recombinant - RKP15151 from Reprokine Category Protein Prices $160.00, $480.00, $1,650.00 Sizes 20 µg, 100 µg, 500 µg Source Optimized DNA sequence encoding Human extracellular domain of human CD155 including a C-terminal 6His tag was expressed in HEK293 cells. Species Human

Recombinant Poliovirus Receptor (PVR) - RPB550Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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