PVR

Gene Symbol PVR
Entrez Gene 5817
Alt Symbol CD155, HVED, NECL5, Necl-5, PVS, TAGE4
Species Human
Gene Type protein-coding
Description poliovirus receptor
Other Description nectin-like protein 5
Swissprots Q96BJ1 P15151 Q15267 B4DTS9 P15152 Q15268
Accessions AAF69803 CAA45478 CAA45479 CAA45480 CBX51265 EAW57284 EAW57285 EAW57286 P15151 AI374885 AK025949 AK094177 BAG52836 AK098812 AK290946 BAF83635 AK300349 BAG62091 BC015542 AAH15542 BE838104 CA416069 DA849917 DC400059 DQ890969 ABM81895 DQ894143 ABM85069 M24406 AAA36462 M24407 AAA36461 XM_005259120 XP_005259177 NM_001135768 NP_001129240 NM_001135769 NP_001129241 NM_001135770 NP_001129242 NM_006505 NP_006496
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing
Subcellular Location Isoform Beta: Secreted.
Top Pathways Cell adhesion molecules (CAMs)

PVR/CD155 (D3G7H) Rabbit mAb - 13544 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3G7H
Western blot analysis of extracts from various cell lines using PVR/CD155 (D3G7H) Rabbit mAb (upper) or α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

CD155 (H-88) - sc-366782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD155 (H-88): sc-366782. Western blot analysis of CD155 expression in non-transfected: sc-117750 (A) and human CD155 transfected: sc-175501 (B) whole cell lysates.

CD155 (S-18) - sc-27754 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD155 (S-18): sc-27754. Western blot analysis of CD155 expression in Hep G2 (A), HeLa (B), MIA PaCa-2 (C), K-562 (D), A549 (E) and SW480 (F) whole cell lysates.

CD155 (SKII.4) - sc-53572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD155 (SKII.4): sc-53572. Western blot analysis of CD155 expression in A549 whole cell lysate under non-reducing conditions.

CD155 (T-19) - sc-27755 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Poliovirus Receptor antibody - ab103630 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Poliovirus Receptor antibody (ab103630) at 1/500 dilution + Mouse stomach tissue lysate at 50 µg

Anti-Poliovirus Receptor antibody - ab123252 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of Human Keratinocytes labeling TCP1 with ab125439 at 1:200. A Dylight 488-conjugated anti-rabbit IgG (1:500) was used as the secondary antibody.

Anti-Poliovirus Receptor antibody [D171] - ab3142 from Abcam

Host Mouse
Clonality Monoclonal
Clone D171
Overlay histogram showing HeLa cells stained with ab3142 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab3142, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-Poliovirus Receptor antibody [D171] (Biotin) - ab79434 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone D171

Anti-PVR / CD155 Antibody (aa35-50) - LS-C14349 from LifeSpan Bioscience

Prices $445.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-PVR / CD155 Antibody (clone D171, Biotin) - LS-C88203 from LifeSpan Bioscience

Prices $305.00, $650.00, $995.00
Sizes 100 µl, 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone D171

Anti-PVR / CD155 Antibody (clone D171) - LS-C88202 from LifeSpan Bioscience

Prices $265.00, $495.00, $755.00
Sizes 20 µg, 500 µl, 200 µg
Host Mouse
Clonality Monoclonal
Clone D171

Anti-PVR / CD155 Antibody (clone D171, Azide-free) - LS-C88204 from LifeSpan Bioscience

Prices $560.00, $810.00
Sizes 100 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone D171

Anti-PVR / CD155 Antibody (clone TX21, FITC) - LS-C179432 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone TX21

Anti-PVR / CD155 Antibody (clone TX21, PE) - LS-C179433 from LifeSpan Bioscience

Prices $345.00
Sizes 50 tst
Host Rat
Clonality Monoclonal
Clone TX21

Anti-PVR / CD155 Antibody (clone TX56, APC) - LS-C107047 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone TX56
Staining of CD4+CD8+ C57Bl/6 thymocytes with 0.5 ug of APC Rat IgG2a isotype control (blue histogram) or 0.5 ug of APC anti-mouse CD155 (purple histogram). Total viable cells were used for analysis.

Anti-PVR / CD155 Antibody (clone 12K48, APC) - LS-C182797 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 12K48

Anti-PVR / CD155 Antibody (clone 11n42, PerCP) - LS-C184200 from LifeSpan Bioscience

Prices $575.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11n42

Anti-PVR / CD155 Antibody (aa314-342, APC) - LS-C267608 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVR / CD155 Antibody (aa314-342, Biotin) - LS-C267609 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVR / CD155 Antibody (aa314-342, AP) - LS-C267610 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVR / CD155 Antibody (aa314-342, FITC) - LS-C267611 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVR / CD155 Antibody (aa314-342, Azide-free, HRP) - LS-C267612 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PVR / CD155 Antibody (aa78-127) - LS-C146055 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PVR / CD155 antibody LS-C146055 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-PVR / CD155 Antibody (aa314-342, PE) - LS-C267616 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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