CEP164

Gene Symbol CEP164
Entrez Gene 22897
Alt Symbol NPHP15
Species Human
Gene Type protein-coding
Description centrosomal protein 164kDa
Other Description centrosomal protein of 164 kDa
Swissprots Q7Z2X9 Q9UPV0 Q9UFJ6 Q9NVS0 Q6PKH9
Accessions CCQ43474 EAW67318 EAW67319 EAW67320 EAW67321 Q9UPV0 AB028975 BAA83004 AK001412 BAA91677 AK125995 BAC86384 AK302991 BAH13870 AK303067 BAG64184 AL117632 CAB56023 AL137265 CAB70664 AL833532 BC000602 AAH00602 BC054015 AAH54015 BC152748 AAI52749 BC156876 AAI56877 BX647583 BX648682 XM_005271453 XP_005271510 XM_005271456 XP_005271513 XM_005271457 XP_005271514 XM_006718788 XP_006718851 XM_006718794 XP_006718857 XM_011542670 XP_011540972 XM_011542671 XP_011540973 XM_011542672 XP_011540974 XM_011542673 XP_011540975 XM_011542674 XP_011540976 XM_011542675 XP_011540977 XM_011542676 XP_011540978 XM_011542677 XP_011540979 XM_011542678 XP_011540980 XM_011542679 XP_011540981 XM_011542680 XP_011540982 XM_011542681 XP_011540983 XM_011542682 XP_011540984 XM_011542683 XP_011540985 XM_011542685 XP_011540987 XM_011542686 XP_011540988 XM_011542687 XP_011540989 XM_011542688 XP_011540990 XM_011542689 XP_011540991 XM_011542690 XP_011540992 XR_428971 XR_947808 XR_947809 XR_947810 XR_947811 NM_001271933 NP_001258862 NM_014956 NP_055771
Function Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1.
Tissue Specificity Expressed in several cell lines. {ECO:0000269|PubMed:17954613}.

CEP164 CRISPR/Cas9 KO Plasmid (h) - sc-403550 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 HDR Plasmid (h) - sc-403550-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 Double Nickase Plasmid (h) - sc-403550-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 Double Nickase Plasmid (h2) - sc-403550-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 CRISPR Activation Plasmid (h) - sc-403550-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 CRISPR Activation Plasmid (h2) - sc-403550-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 Lentiviral Activation Particles (h) - sc-403550-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 Lentiviral Activation Particles (h2) - sc-403550-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 siRNA (h) - sc-96897 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CEP164 shRNA Plasmid (h) - sc-96897-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CEP164 shRNA (h) Lentiviral Particles - sc-96897-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU148991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5961 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5961 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08096 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08096

CEP164 siRNA (Human) - CRH7852 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CEP164 - MBS8217028 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CEP164 CRISPR/Cas9 KO Plasmid (h2) - sc-403550-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CEP164 HDR Plasmid (h2) - sc-403550-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human Cep164 (NM_014956.4) - SHH261837 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CEP164(NM_014956.4) - SHG168765 from Creative biogene

Category siRNA
Species Reactivities Human

CEP164 shRNA Plasmid (Human) - CHH7852 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CEP164 miRNA 3'UTR clone - MiUTR1H-02050 from Creative biogene

Species Reactivities Human
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