CD274

Gene Symbol	CD274
Entrez Gene	29126
Alt Symbol	B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Species	Human
Gene Type	protein-coding
Description	CD274 molecule
Other Description	B7 homolog 1|CD274 antigen|PDCD1 ligand 1|programmed cell death 1 ligand 1|programmed death ligand 1
Swissprots	Q9NUZ5 Q6WEX4 B4DU27 Q14CJ2 Q2V8D5 Q9NZQ7 Q66RK1 B2RBA2
Accessions	CCF77002 EAW58763 Q9NZQ7 AF177937 AAF25807 AF233516 AAG18508 AI826502 AK001894 BAA91966 AK300470 BAG62189 AK314567 BAG37149 AY254342 AAP13470 AY291313 AAP42144 AY714881 AAU09634 BC069381 AAH69381 BC074984 AAH74984 BC113734 AAI13735 BC113736 AAI13737 DQ286582 ABB90152 DQ836393 ABI16084 HQ258151 ADR82905 XM_006716759 XP_006716822 NM_001267706 NP_001254635 NM_014143 NP_054862 NR_052005
Function	Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD274 overexpression lysate - LY415473 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD274 293 Cell Lysate - 407288 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PD-L1/B7-H1 Overexpression Lysate (Native) - NBP2-07377 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CD274 Over-expression Lysate Product - GWB-D2CEA8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cynomolgus / Rhesus PD-L1 / B7-H1 / CD274 HEK293 Cell Lysate (WB positive control) - 90251-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus PD-L1 / B7-H1 / CD274 HEK293 Cell Lysate (WB positive control) - 90251-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human PD-L1 / B7-H1 / CD274 HEK293 Cell Lysate (WB positive control) - 10084-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PD-L1 HEK293 Cell Lysate (WB positive control) - 10084-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PD-L1 Human Cells Transfected Lysate (positive control) (denatured) - orb172784 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Panoply™ Human CD274 Knockdown Stable Cell Line - CSC-DC002726 from Creative biogene Category Cell Line Species Human

Human CD274 Knockout Cell Line-HeLa - CSC-RT1751 from Creative biogene Category Cell Line Species Human

CD274 KO Cell Lysate-HeLa - CLKO-1598 from Creative biogene Category Cell Lysate

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