| Gene Symbol |
MICA
|
| Entrez Gene |
100507436
|
| Alt Symbol |
MIC-A, PERB11.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MHC class I polypeptide-related sequence A
|
| Other Description |
HLA class I antigen|MHC class I chain-related protein A|stress inducible class I homolog
|
| Swissprots |
Q9TQL2 Q9BCR8 Q9TQ89 P79516 Q9UE05 P79506 P79521 Q9BCS0 Q9GJ09 Q9GJ05 P79507 O97990 Q95IB2 Q9GJ04 Q9GJ06 Q9GIZ5 Q95HD6 Q29983 P79515 Q9TQL1 Q9BCS2 O97992 O97995 Q95HA2 Q7YQ98 Q9TQA2 Q9TQI9 Q7JFH9 O78150 Q9GIZ1 P79517 O97989 Q9GIZ6 Q70I48 A9QVE0 O78152 O98234 Q9TQJ9 Q9GJ02 O60920 A8KQR0 Q9BCR5 Q9BCR6 O78153 Q9TQA1 Q5XM81 Q9BCR7 P79508 Q9TQL0 Q9TQK0 O60918 Q95IY7 Q9TQL4 Q9TQA3 Q9GJ01 Q9GJ07 Q95HN6 Q99692 Q70I49 Q95HN4 O98237 O98238 Q9BCR9 Q9UE04 Q7JFI0 P79512 Q9UE06 Q9TQA0 Q9TQ87 Q9TQK1 O97993 Q7JFI1 Q861I1 O98235 O60933 O78151 P79518 Q9BD20 O60919 Q9TQ93 Q9MY21 Q9BCS3 P79513 Q95HN5 Q9TQ88 Q9TQK9 Q9TQ95 Q9BCR4 O98236 Q9TQA4 Q9GIZ2 B1VJF1 Q9GJ03 O60917 P79511 Q9TQK2 P79510 A9LRW5 Q9UE11 Q9TQK8 O97994 P79509 O77956 O97988 Q9TQL3 P79514 Q9BCS4 Q9TQ97 Q7JFI2 Q9TQ99 Q9GJ08 Q5C9P8 O97991 Q9TQJ0 Q9BCS1 P79520 Q9TQ96 O97987 Q9TQ94 Q9BCR3 Q9GIZ4 Q9GIZ3 Q95464 Q9TQ92 P79519 Q9TQ98 Q9TQ86 Q9TQJ1
|
| Accessions |
AAA52662 AAA64611 AAB41060 AAB41061 AAB41062 AAB41063 AAB41064 AAB41065 AAB41066 AAB41067 AAB41068 AAB41069 AAB41070 AAB41071 AAB41072 AAB41073 AAB41074 AAB41075 AAB51778 AAB51779 AAB51780 AAB51781 AAB51782 AAB51783 AAB51784 AAB51785 AAB51786 AAB51787 AAB51788 AAB51789 AAB51790 AAB51791 AAB51792 AAB51793 AAB51794 AAB51795 AAB51796 AAB51797 AAB51798 AAB51799 AAB51800 AAB51801 AAD19604 AAD27006 AAD27007 AAD27008 AAD27009 AAG22082 AAG22083 AAG22086 AAG22087 AAM34484 AAV39504 ABX54884 ABX60404 ABY64780 ABY64781 ABY74342 ACM48568 ACN53534 ACN53535 ACN76810 ACT78510 ADD73556 ADF58430 ADI24780 ADX53323 AEA92278 AEA92279 AEA92280 AEA92281 AEA92282 AEA92283 AEA92284 AEA92285 AEA92286 AEL17652 AER12792 AET81009 AEV66149 AFA53234 AFC96907 AFQ37277 AFR69318 AFR69319 AFS41249 AFS41250 AFS41251 AGB57986 AGE11866 AGF90790 AGF90791 AGF90792 AGF90793 AGG38021 AGG38022 AHA98257 AHA98258 AHI16961 AHL96300 AHW98077 AHX74088 AHX74089 AKE78870 BAA29034 BAB63308 BAC54940 BAE78633 BAF31275 BAI52964 CAA63427 CAA76393 CAA76394 CAA76395 CAA76396 CAA76397 CAA76398 CAA76399 CAA76400 CAA76401 CAA76402 CAA76403 CAA77029 CAA77030 CAA77031 CAA77032 CAA77033 CAA77034 CAA77035 CAA77036 CAA77037 CAB71317 CAC14280 CAC14281 CAC14282 CAC14283 CAC14284 CAC14285 CAC14286 CAC14287 CAC14288 CAC15380 CAC15381 CAC15382 CAC15383 CAC16142 CAC16143 CAC27561 CAC88121 CAD91415 CAE45581 CAE45582 CAI64221 CAP12057 CAQ16171 CBY85065 CCD30535 CCD30536 CDM87276 CDM87277 EAX03392 EAX03393 EAX03394 EAX03395 EAX03396 EAX03397 Q29983 AB506764 BAH83534 AK094237 AK225393 AK299135 BAG61187 AK310028 AK311667 AY204547 AAO45822 AY750850 AAU95072 BC016929 AAH16929 BM552351 BM991681 BX342160 CN483948 DT219772 L14848 AAA21718 NM_000247 NP_000238 NM_001177519 NP_001170990 NM_001289152 NP_001276081 NM_001289153 NP_001276082 NM_001289154 NP_001276083
|
| Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}; Single- pass type I membrane protein {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Cytoplasm {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}.
|
| Tissue Specificity |
Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells. {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:10691930, ECO:0000269|PubMed:12902493, ECO:0000269|PubMed:17565371, ECO:0000269|PubMed:8901601, ECO:0000269|PubMed:9396860}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|
![All lanes : Anti-MICA antibody [EPR6568] (ab150355) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLane 3 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_3/22543_MICA-Primary-antibodies-ab150355-1.jpg)
