Gene Symbol | HYAL4 |
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Entrez Gene | 23553 |
Alt Symbol | CSHY |
Species | Human |
Gene Type | protein-coding |
Description | hyaluronoglucosaminidase 4 |
Other Description | chondroitin sulfate endo-beta-N-acetylgalactosaminidase|chondroitin sulfate hydrolase|hyal-4|hyaluronidase 4|hyaluronidase-4|hyaluronoglucosaminidase-4 |
Swissprots | Q2M3T9 D0VXG1 Q9Y6T9 Q9UL99 |
Accessions | AAD43186 EAL24331 EAW83603 Q2M3T9 AB470346 BAI49593 AF009010 AAC98883 BC104788 AAI04789 BC104790 AAI04791 BC143654 BF085228 BG013757 XM_011515990 XP_011514292 XM_011515991 XP_011514293 XM_011515992 XP_011514294 XR_927425 NM_012269 NP_036401 |
Function | Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. {ECO:0000269|PubMed:16104017, ECO:0000269|PubMed:19889881}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in placenta and skeletal muscle. {ECO:0000269|PubMed:10493834}. |
Top Pathways | Glycosaminoglycan degradation |
HYAL4 CRISPR/Cas9 KO Plasmid (h) - sc-409245 from Santa Cruz Biotechnology
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HYAL4 HDR Plasmid (h) - sc-409245-HDR from Santa Cruz Biotechnology
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HYAL4 Double Nickase Plasmid (h) - sc-409245-NIC from Santa Cruz Biotechnology
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HYAL4 Double Nickase Plasmid (h2) - sc-409245-NIC-2 from Santa Cruz Biotechnology
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HYAL4 CRISPR Activation Plasmid (h) - sc-409245-ACT from Santa Cruz Biotechnology
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HYAL4 CRISPR Activation Plasmid (h2) - sc-409245-ACT-2 from Santa Cruz Biotechnology
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HYAL4 Lentiviral Activation Particles (h) - sc-409245-LAC from Santa Cruz Biotechnology
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HYAL4 Lentiviral Activation Particles (h2) - sc-409245-LAC-2 from Santa Cruz Biotechnology
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HYAL4 siRNA (h) - sc-60828 from Santa Cruz Biotechnology
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HYAL4 shRNA Plasmid (h) - sc-60828-SH from Santa Cruz Biotechnology
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HYAL4 shRNA (h) Lentiviral Particles - sc-60828-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU048101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10413 from Sigma-Aldrich
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HYAL4 siRNA (Human) - CRH8355 from Cohesion Biosciences
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HYAL4 - MBS8239192 from MyBioSource
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shRNA set against Human HYAL4 (NM_012269.2) - SHH316185 from Creative biogene
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shRNA set against Human HYAL4(NM_012269.2) - SHH137045 from Creative biogene
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Human HYAL4 siRNA - orb268857 from Biorbyt
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HYAL4 shRNA Plasmid (Human) - CHH8355 from Cohesion Biosciences
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HYAL4 miRNA 3'UTR clone - MiUTR1H-04766 from Creative biogene
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