| Gene Symbol | Fgf2 |
|---|---|
| Entrez Gene | 14173 |
| Alt Symbol | Fgf-2, Fgfb, bFGF |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | fibroblast growth factor 2 |
| Other Description | HBGF-2|basic fibroblast growth factor|heparin-binding growth factor 2 |
| Swissprots | P15655 |
| Accessions | AAK53871 AAP92384 AAP92385 EDL35104 EDL35105 EDL35106 EDL35107 EDL35108 P15655 AF065903 AAC17503 AF065904 AAC17504 AF065905 AAC17505 AY027548 AY027549 AY027550 AY027551 AAK52308 AY027557 AAK52309 AY027558 AAK52310 AY027559 BC156158 AAI56159 BC156994 AAI56995 BY730691 CJ098597 M30644 AAA37621 XM_006502586 XP_006502649 XM_006535398 XP_006535461 XM_006535399 XP_006535462 NM_008006 NP_032032 |
| Function | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. Nucleus {ECO:0000250}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250}. |
| Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway |
FGF-2 CRISPR/Cas9 KO Plasmid (m) - sc-420332 from Santa Cruz Biotechnology
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FGF-2 HDR Plasmid (m) - sc-420332-HDR from Santa Cruz Biotechnology
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FGF-2 Double Nickase Plasmid (m) - sc-420332-NIC from Santa Cruz Biotechnology
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FGF-2 Double Nickase Plasmid (m2) - sc-420332-NIC-2 from Santa Cruz Biotechnology
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FGF-2 CRISPR Activation Plasmid (m) - sc-420332-ACT from Santa Cruz Biotechnology
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FGF-2 CRISPR Activation Plasmid (m2) - sc-420332-ACT-2 from Santa Cruz Biotechnology
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FGF-2 Lentiviral Activation Particles (m) - sc-420332-LAC from Santa Cruz Biotechnology
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FGF-2 Lentiviral Activation Particles (m2) - sc-420332-LAC-2 from Santa Cruz Biotechnology
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FGF-2 siRNA (m) - sc-39447 from Santa Cruz Biotechnology
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FGF-2 shRNA Plasmid (m) - sc-39447-SH from Santa Cruz Biotechnology
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FGF-2 shRNA (m) Lentiviral Particles - sc-39447-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU046231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31355 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31355 from Sigma-Aldrich
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FGF2 siRNA (Mouse) - CRM1348 from Cohesion Biosciences
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FGF2 - MBS8232755 from MyBioSource
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shRNA set against Mouse FGF2 (NM_008006.2) - SHH294485 from Creative biogene
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shRNA set against Mouse Fgf2(NM_008006.2) - SHH057421 from Creative biogene
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FGF-2 CRISPR/Cas9 KO Plasmid (m2) - sc-420332-KO-2 from Santa Cruz Biotechnology
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FGF-2 HDR Plasmid (m2) - sc-420332-HDR-2 from Santa Cruz Biotechnology
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Mouse FGF2 siRNA - orb280824 from Biorbyt
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FGF2 shRNA Plasmid (Mouse) - CHM1348 from Cohesion Biosciences
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FGF2 miRNA 3'UTR clone - MiUTR1M-04691 from Creative biogene
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