| Gene Symbol |
M6PR
|
| Entrez Gene |
4074
|
| Alt Symbol |
CD-MPR, MPR 46, MPR-46, MPR46, SMPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannose-6-phosphate receptor (cation dependent)
|
| Other Description |
46-kDa mannose 6-phosphate receptor|CD Man-6-P receptor|Mr 46,000 Man6PR|cation-dependent mannose-6-phosphate receptor|small mannose 6-phosphate receptor
|
| Swissprots |
D3DUV5 A8K528 P20645
|
| Accessions |
CAB94715 CAD48709 CAF06410 EAW88596 EAW88597 EAW88598 EAW88599 P20645 AA648974 AK057556 AK222792 BAD96512 AK291143 BAF83832 AK312689 BAG35569 BC017111 AAH17111 BC024206 AAH24206 BG750588 BM546062 BU166950 CR457412 CAG33693 DC341018 HQ447561 ADQ32047 M16985 AAA59542 XM_005253376 XP_005253433 XM_011520672 XP_011518974 NM_001207024 NP_001193953 NM_002355 NP_002346
|
| Function |
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
|
| Subcellular Location |
Lysosome membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Lysosome, Phagosome
|
![Western Blot: Mannose 6 Phosphate Receptor (Cation dependent) Overexpression Lysate (Adult Normal) [NBP2-10825] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Mannose 6 Phosphate Receptor (Cation dependent).](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7358_Mannose%25206%2520Phosphate%2520Receptor%2520(Cation%2520dependent)%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10825-img0001.jpg)