| Gene Symbol |
SLC17A4
|
| Entrez Gene |
10050
|
| Alt Symbol |
KAIA2138
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 17, member 4
|
| Other Description |
Na/PO4 cotransporter|probable small intestine urate exporter|putative small intestine sodium-dependent phosphate transport protein|solute carrier family 17 (sodium phosphate), member 4
|
| Swissprots |
E7EU17 E7EPE8 Q32MB8 Q9Y2C5 B4DDV9 Q32MB7
|
| Accessions |
EAW55492 EAW55493 Q9Y2C5 AB020527 BAA76663 AK024903 AK293354 BAG56870 AK308500 BC109207 AAI09208 BC109208 AAI09209 XM_011514206 XP_011512508 XM_011514207 XP_011512509 XM_011514208 XP_011512510 XM_011514209 XP_011512511 XM_011514210 XP_011512512 XM_011514211 XP_011512513 XM_011514212 XP_011512514 XM_011514213 XP_011512515 XM_011514214 XP_011512516 XM_011514215 XP_011512517 XM_011514216 XP_011512518 XM_011514217 XP_011512519 XM_011514218 XP_011512520 XM_011514219 XP_011512521 XR_925996 XR_925997 XR_925998 XR_925999 NM_001286121 NP_001273050 NM_005495 NP_005486
|
| Function |
Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). {ECO:0000269|PubMed:22460716}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000269|PubMed:22460716}. Cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000269|PubMed:22460716}. Note=Apical in the intestinal brush border.
|
| Tissue Specificity |
Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs. {ECO:0000269|PubMed:10319585, ECO:0000269|PubMed:22460716}.
|
