CTNS

Gene Symbol CTNS
Entrez Gene 1497
Alt Symbol CTNS-LSB, PQLC4
Species Human
Gene Type protein-coding
Description cystinosin, lysosomal cystine transporter
Other Description cystinosin
Swissprots Q9UNK6 D3DTJ5 O60931 Q8IZ01
Accessions AAF43102 CAA75882 EAW90494 EAW90495 EAW90496 O60931 AJ222967 CAA11021 AK292019 BAF84708 AK296178 BAG58913 AK297525 BAG59928 AK309044 AK309651 BC032850 AAH32850 BX369529 CA454595 CR542058 CAG46855 DB026195 JF432879 ADZ16096 XM_005256485 XP_005256542 XM_006721463 XP_006721526 XM_006721464 XP_006721527 XM_011523691 XP_011521993 XM_011523692 XP_011521994 XR_934003 NM_001031681 NP_001026851 NM_004937 NP_004928
Function Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR. {ECO:0000269|PubMed:22649030}.
Subcellular Location Isoform 1: Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Melanosome {ECO:0000269|PubMed:22649030}.
Tissue Specificity Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions. {ECO:0000269|PubMed:22649030}.
Top Pathways Lysosome

Cystinosin (H-100) - sc-134899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Cystinosin (F-12) - sc-100703 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cystinosin (F-12): sc-100703. Western blot analysis of Cystinosin expression in Hep G2 whole cell lysate.

Anti-CTNS antibody - ab64175 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab64175 at 1.25µg/ml staining CTNS in human skeletal muscle by Immunohistochemistry, Formalin-fixed, paraffin-embedded tissue.

Anti-CTNS antibody [5G6] - ab192651 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5G6
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling CTNS with ab192651 at 1/100.

Anti-CTNS antibody - C-terminal - ab174516 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CTNS antibody - C-terminal (ab174516) at 1/100 dilution + HepG2 lysate at 35 µg

Anti-CTNS antibody - N-terminal - ab194444 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-CTNS antibody - N-terminal (ab194444) at 1/2500 dilution + CTNS recombinant protein (immunizing peptide) at 0.2 µg

Anti-CTNS / Cystinosin Antibody (aa340-367, AP) - LS-C255667 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367, APC) - LS-C255668 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367, Biotin) - LS-C255669 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367, FITC) - LS-C255670 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367) - LS-C157668 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CTNS Antibody western blot of HepG2 cell line lysates (35 ug/lane). The CTNS antibody detected the CTNS protein (arrow).

Anti-CTNS / Cystinosin Antibody (aa340-367, Azide-free, HRP) - LS-C255671 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367, PE) - LS-C255672 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody - LS-C310074 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa340-367) - LS-C320669 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNS / Cystinosin Antibody (aa268-285) IHC-plus™ - LS-B205 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CTNS antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B205 concentration 25 ug/ml.

Anti-CTNS / Cystinosin Antibody (Internal) - LS-C345867 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Ctns Antibody - middle region in Mouse Lung cells lysate.

Anti-CTNS / Cystinosin Antibody - LS-C334968 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using CTNS antibody. Blue: DAPI for nuclear staining.

Anti-CTNS / Cystinosin Antibody (clone 5G6) IHC-plus™ - LS-B10982 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5G6
Anti-CTNS / Cystinosin antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10982 dilution 1:100.

CTNS Antibody (5G6) - H00001497-M09 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5G6
Western Blot: CTNS Antibody (5G6) [H00001497-M09] - Analysis of CTNS expression in Raw 264.7.

CTNS Antibody - H00001497-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CTNS Antibody [H00001497-D01P] - CTNS MaxPab rabbit polyclonal antibody. Western Blot analysis of CTNS expression in MCF-7.

CTNS Antibody - NBP1-02469 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CTNS Antibody - H00001497-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CTNS Antibody [H00001497-A01] - CTNS polyclonal antibody (A01), Lot # 060623JCS1 Western Blot analysis of CTNS expression in HeLa ( Cat # L013V1 ).

CTNS Polyclonal Antibody - bs-12932R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-CTNS Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12932R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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