CTNS

Gene Symbol	CTNS
Entrez Gene	1497
Alt Symbol	CTNS-LSB, PQLC4
Species	Human
Gene Type	protein-coding
Description	cystinosin, lysosomal cystine transporter
Other Description	cystinosin
Swissprots	Q9UNK6 D3DTJ5 O60931 Q8IZ01
Accessions	AAF43102 CAA75882 EAW90494 EAW90495 EAW90496 O60931 AJ222967 CAA11021 AK292019 BAF84708 AK296178 BAG58913 AK297525 BAG59928 AK309044 AK309651 BC032850 AAH32850 BX369529 CA454595 CR542058 CAG46855 DB026195 JF432879 ADZ16096 XM_005256485 XP_005256542 XM_006721463 XP_006721526 XM_006721464 XP_006721527 XM_011523691 XP_011521993 XM_011523692 XP_011521994 XR_934003 NM_001031681 NP_001026851 NM_004937 NP_004928
Function	Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR. {ECO:0000269|PubMed:22649030}.
Subcellular Location	Isoform 1: Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Melanosome {ECO:0000269|PubMed:22649030}.
Tissue Specificity	Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions. {ECO:0000269|PubMed:22649030}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CTNS full length protein - ab158228 from Abcam Category Protein Source Wheat germ Species Human

Human CTNS protein fragment - ab158229 from Abcam Category Protein Source Wheat germ Species Human

CTNS / Cystinosin Antibody Blocking Peptide - LS-E6618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CTNS Protein - H00001497-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CTNS-AntibodyC-term-Blocking-peptide - BP19410b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cystinosin - H00001497-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Cystinosin - H00001497-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Cystinosin - H00001497-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Cystinosin - H00001497-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cystinosin - H00001497-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cystinosis, Nephropathic (CTNS), Human - 20-9446 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

CTNS fusion protein - ag3904 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Cystinosis, Nephropathic (CTNS) - RPL140Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cystinosis, Nephropathic (CTNS) - RPL140Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human CTNS Protein - H00001497-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Cystinosin (transcript variant 2) - TP313151 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CTNS Peptide, Human - M34GP03807H from Creative Peptides Category Peptide Source Synthetic. Species Human

CTNS Recombinant Protein Antigen - NBP2-56839PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Cystinosin (CTNS), Recombinant Protein - MBS7013221 from MyBioSource Category Protein Prices $1,175.00, $2,160.00, $3,370.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Cystinosin (CTNS), Recombinant Protein - MBS1176207 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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