| Gene Symbol |
SPC24
|
| Entrez Gene |
147841
|
| Alt Symbol |
SPBC24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SPC24, NDC80 kinetochore complex component
|
| Other Description |
SPC24, NDC80 kinetochore complex component, homolog|hSpc24|kinetochore protein Spc24|spindle pole body component 24 homolog
|
| Swissprots |
C9JGC4 Q8NBT2 B4DZZ7
|
| Accessions |
CAF86972 EAW84174 Q8NBT2 AK075287 BAC11523 AK303157 BAG64259 AK303266 BAG64348 AY456387 AAR88651 BC105037 AAI05038 BC105039 AAI05040 XM_005259753 XP_005259810 XM_011527701 XP_011526003 XM_011527702 XP_011526004 XR_936158 NM_182513 NP_872319
|
| Function |
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:14738735}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
|
![Western Blot: SPC24 Overexpression Lysate (Adult Normal) [NBL1-16386] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPC24.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9543_SPC24%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16386-img0002.jpg)