Gene Symbol | SPC24 |
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Entrez Gene | 147841 |
Alt Symbol | SPBC24 |
Species | Human |
Gene Type | protein-coding |
Description | SPC24, NDC80 kinetochore complex component |
Other Description | SPC24, NDC80 kinetochore complex component, homolog|hSpc24|kinetochore protein Spc24|spindle pole body component 24 homolog |
Swissprots | C9JGC4 Q8NBT2 B4DZZ7 |
Accessions | CAF86972 EAW84174 Q8NBT2 AK075287 BAC11523 AK303157 BAG64259 AK303266 BAG64348 AY456387 AAR88651 BC105037 AAI05038 BC105039 AAI05040 XM_005259753 XP_005259810 XM_011527701 XP_011526003 XM_011527702 XP_011526004 XR_936158 NM_182513 NP_872319 |
Function | Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269|PubMed:14738735}. |
Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. |
Spc24 CRISPR/Cas9 KO Plasmid (h) - sc-414619 from Santa Cruz Biotechnology
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Spc24 HDR Plasmid (h) - sc-414619-HDR from Santa Cruz Biotechnology
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Spc24 Double Nickase Plasmid (h) - sc-414619-NIC from Santa Cruz Biotechnology
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Spc24 Double Nickase Plasmid (h2) - sc-414619-NIC-2 from Santa Cruz Biotechnology
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Spc24 CRISPR Activation Plasmid (h) - sc-414619-ACT from Santa Cruz Biotechnology
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Spc24 CRISPR Activation Plasmid (h2) - sc-414619-ACT-2 from Santa Cruz Biotechnology
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Spc24 Lentiviral Activation Particles (h) - sc-414619-LAC from Santa Cruz Biotechnology
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Spc24 Lentiviral Activation Particles (h2) - sc-414619-LAC-2 from Santa Cruz Biotechnology
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Spc24 siRNA (h) - sc-76552 from Santa Cruz Biotechnology
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Spc24 shRNA Plasmid (h) - sc-76552-SH from Santa Cruz Biotechnology
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Spc24 shRNA (h) Lentiviral Particles - sc-76552-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20435 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20435 from Sigma-Aldrich
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SPC24 siRNA (Human) - CRJ5546 from Cohesion Biosciences
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SPC24 - MBS8216295 from MyBioSource
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shRNA set against Human SPC24 (NM_182513.2) - SHH416288 from Creative biogene
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shRNA set against Human SPC24(NM_182513.2) - SHR003328 from Creative biogene
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Human SPC24 siRNA - orb276047 from Biorbyt
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SPC24 shRNA Plasmid (Human) - CHJ5546 from Cohesion Biosciences
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SPC24 miRNA 3'UTR clone - MiUTR1H-09825 from Creative biogene
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