| Gene Symbol | Acot1 |
|---|---|
| Entrez Gene | 26897 |
| Alt Symbol | ACH2, CTE-1, CTE-I, Cte1, D12Ucla1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 1 |
| Other Description | acyl-CoA thioesterase 1, cytosolic|acyl-coenzyme A thioesterase 1|cytosolic acyl-CoA thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase |
| Swissprots | Q549A9 O55137 |
| Accessions | AAF13870 O55137 AK053680 BC003911 AAH03911 BC022951 BC028261 AAH28261 BC040749 Y14004 CAA74327 NM_012006 NP_036136 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low activity with decanoyl-CoA as substrate. Most active on myristoyl- and palmitoyl-CoA. Introduction of one or two double bonds decreases the activity to about half. No detectable activity with bile acid CoAs such as choloyl-CoA and chenodeoxycholoyl-CoA. {ECO:0000269|PubMed:10567408}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. {ECO:0000269|PubMed:10567408, ECO:0000269|PubMed:11330065}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids |