| Gene Symbol |
Acot1
|
| Entrez Gene |
26897
|
| Alt Symbol |
ACH2, CTE-1, CTE-I, Cte1, D12Ucla1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA thioesterase 1
|
| Other Description |
acyl-CoA thioesterase 1, cytosolic|acyl-coenzyme A thioesterase 1|cytosolic acyl-CoA thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase
|
| Swissprots |
Q549A9 O55137
|
| Accessions |
AAF13870 O55137 AK053680 BC003911 AAH03911 BC022951 BC028261 AAH28261 BC040749 Y14004 CAA74327 NM_012006 NP_036136
|
| Function |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low activity with decanoyl-CoA as substrate. Most active on myristoyl- and palmitoyl-CoA. Introduction of one or two double bonds decreases the activity to about half. No detectable activity with bile acid CoAs such as choloyl-CoA and chenodeoxycholoyl-CoA. {ECO:0000269|PubMed:10567408}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. {ECO:0000269|PubMed:10567408, ECO:0000269|PubMed:11330065}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids
|