| Gene Symbol |
PRSS1
|
| Entrez Gene |
5644
|
| Alt Symbol |
TRP1, TRY1, TRY4, TRYP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protease, serine, 1 (trypsin 1)
|
| Other Description |
TCR V beta 4.1|beta-trypsin|cationic trypsinogen|digestive zymogen|nonfunctional trypsin 1|trypsin-1|trypsinogen 1|trypsinogen A
|
| Swissprots |
A6NJ71 Q9HAN4 P07477 Q5NV57 Q9HAN6 Q9HAN5 A1A509 Q7M4N4 B2R5I5 Q9HAN7 Q7M4N3 Q92955
|
| Accessions |
AAC50728 AAC80207 AAG30943 AAG30947 AAG30948 AAG30949 AAO85796 AAO85797 AAO85798 AAO85799 AAO85800 AAO85801 AAO85802 AAP42827 AAP42828 AAP59550 AAP74363 AAP74364 AAZ40216 CAL49864 EAL23773 EAW51925 P07477 AA835201 AB306150 BAF94843 AB306221 BAF94914 AB306223 BAF94916 AB306246 BAF94939 AB306249 BAF94942 AK293375 BAG56887 AK312199 BAG35132 AY006147 AAG15650 BC035777 BC128226 AAI28227 BP321959 BP321999 CA948204 CR627200 DQ778083 ABI63347 M22612 AAA61231 S60788 AAD13920 XM_011516411 XP_011514713 NM_002769 NP_002760
|
| Function |
Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. {ECO:0000269|PubMed:7945238}.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Top Pathways |
Protein digestion and absorption, Pancreatic secretion, Influenza A, Neuroactive ligand-receptor interaction
|
![Western Blot: Trypsin Overexpression Lysate (Adult Normal) [NBL1-14841] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Trypsin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4358_Trypsin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14841-img0002.jpg)