Gene Symbol | PRSS1 |
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Entrez Gene | 5644 |
Alt Symbol | TRP1, TRY1, TRY4, TRYP1 |
Species | Human |
Gene Type | protein-coding |
Description | protease, serine, 1 (trypsin 1) |
Other Description | TCR V beta 4.1|beta-trypsin|cationic trypsinogen|digestive zymogen|nonfunctional trypsin 1|trypsin-1|trypsinogen 1|trypsinogen A |
Swissprots | A6NJ71 Q9HAN4 P07477 Q5NV57 Q9HAN6 Q9HAN5 A1A509 Q7M4N4 B2R5I5 Q9HAN7 Q7M4N3 Q92955 |
Accessions | AAC50728 AAC80207 AAG30943 AAG30947 AAG30948 AAG30949 AAO85796 AAO85797 AAO85798 AAO85799 AAO85800 AAO85801 AAO85802 AAP42827 AAP42828 AAP59550 AAP74363 AAP74364 AAZ40216 CAL49864 EAL23773 EAW51925 P07477 AA835201 AB306150 BAF94843 AB306221 BAF94914 AB306223 BAF94916 AB306246 BAF94939 AB306249 BAF94942 AK293375 BAG56887 AK312199 BAG35132 AY006147 AAG15650 BC035777 BC128226 AAI28227 BP321959 BP321999 CA948204 CR627200 DQ778083 ABI63347 M22612 AAA61231 S60788 AAD13920 XM_011516411 XP_011514713 NM_002769 NP_002760 |
Function | Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. {ECO:0000269|PubMed:7945238}. |
Subcellular Location | Secreted, extracellular space. |
Top Pathways | Protein digestion and absorption, Pancreatic secretion, Influenza A, Neuroactive ligand-receptor interaction |
Active cow Trypsin full length protein - ab93263 from Abcam
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Active human Trypsin full length protein - ab78527 from Abcam
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Active pig Trypsin full length protein - ab101090 from Abcam
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Human PRSS1 full length protein - ab159242 from Abcam
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Human PRSS1 full length protein - ab191806 from Abcam
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Human PRSS1 protein fragment - ab159243 from Abcam
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PRSS1-Antibody-Center-Blocking-peptide - BP10735c from Abgent, a WuXi AppTec company
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Recombinant Human Trypsin 1/PRSS1, CF - 3848-SE-010 from R&D Systems
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Human Trypsin Protein (OPMA04257) - OPMA04257 from Aviva Systems Biology
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Human Trypsin 1 protein - orb180432 from Biorbyt
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Human Protease, Serine 1 Protein - abx068707 from Abbexa
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Trypsin-1 / PRSS1 - BA630 from Acris Antibodies
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Trypsin-1 / PRSS1 - H00005644-P01-10 from Acris Antibodies
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Trypsin-1 / PRSS1 - H00005644-P01-25 from Acris Antibodies
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Trypsin-1 / PRSS1 - H00005644-Q01-10 from Acris Antibodies
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Trypsin-1 / PRSS1 - H00005644-Q01-25 from Acris Antibodies
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Trypsin Substrate Peptide - 350013 from ABBIOTEC
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Trypsin Substrate Peptide - 350577 from ABBIOTEC
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Recombinant Human PRSS1, His-tagged - PRSS1-1047H from Creative Biomart
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Recombinant Human PRSS1, His-tagged - PRSS1-516H from Creative Biomart
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Native Human PRSS1 - PRSS1-30745TH from Creative Biomart
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Recombinant Protease, Serine 1 (PRSS1) - RPA230Hu01 from Uscn Life Science Inc.
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Recombinant Protease, Serine 1 (PRSS1) - RPA230Ra01 from Uscn Life Science Inc.
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Trypsin, Human Pancreas - HTRYP from Molecular Innovations
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Trypsin 1 Blocking Peptide - CBP1955 from Cohesion Biosciences
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