Gene Symbol | STXBP4 |
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Entrez Gene | 252983 |
Alt Symbol | Synip |
Species | Human |
Gene Type | protein-coding |
Description | syntaxin binding protein 4 |
Other Description | STX4-interacting protein|syntaxin 4 interacting protein|syntaxin 4-interacting protein|syntaxin-binding protein 4 |
Swissprots | Q8IVZ5 Q6ZWJ1 |
Accessions | EAW94545 EAW94546 Q6ZWJ1 AK122865 BAC85511 AK123793 BC041485 AAH41485 BC125116 AAI25117 CA848494 XM_005257187 XP_005257244 XM_006721797 XP_006721860 XM_006721798 XP_006721861 XM_011524581 XP_011522883 XM_011524582 XP_011522884 XM_011524583 XP_011522885 XM_011524584 XP_011522886 XR_934431 NM_178509 NP_848604 |
Function | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Synip CRISPR/Cas9 KO Plasmid (h) - sc-408351 from Santa Cruz Biotechnology
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Synip HDR Plasmid (h) - sc-408351-HDR from Santa Cruz Biotechnology
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Synip Double Nickase Plasmid (h) - sc-408351-NIC from Santa Cruz Biotechnology
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Synip Double Nickase Plasmid (h2) - sc-408351-NIC-2 from Santa Cruz Biotechnology
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Synip CRISPR Activation Plasmid (h) - sc-408351-ACT from Santa Cruz Biotechnology
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Synip CRISPR Activation Plasmid (h2) - sc-408351-ACT-2 from Santa Cruz Biotechnology
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Synip Lentiviral Activation Particles (h) - sc-408351-LAC from Santa Cruz Biotechnology
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Synip Lentiviral Activation Particles (h2) - sc-408351-LAC-2 from Santa Cruz Biotechnology
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Synip siRNA (h) - sc-106584 from Santa Cruz Biotechnology
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Synip shRNA Plasmid (h) - sc-106584-SH from Santa Cruz Biotechnology
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Synip shRNA (h) Lentiviral Particles - sc-106584-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20794 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20794 from Sigma-Aldrich
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STXBP4 siRNA (Human) - CRJ6631 from Cohesion Biosciences
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STXBP4 - MBS8212397 from MyBioSource
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shRNA set against Human STXBP4 (NM_178509.5) - SHH420472 from Creative biogene
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Human STXBP4 siRNA - orb277132 from Biorbyt
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STXBP4 shRNA Plasmid (Human) - CHJ6631 from Cohesion Biosciences
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STXBP4 miRNA 3'UTR clone - MiUTR1H-10039 from Creative biogene
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