Gene Symbol | SLC25A28 |
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Entrez Gene | 81894 |
Alt Symbol | MFRN2, MRS3/4, MRS4L, NPD016 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (mitochondrial iron transporter), member 28 |
Other Description | hMRS3/4|mitochondrial RNA splicing protein 3/4|mitochondrial RNA-splicing protein 3/4 homolog|mitochondrial iron transporter 2|mitoferrin 2|mitoferrin-2|putative mitochondrial solute carrier|solute carrier family 25, member 28 |
Swissprots | Q5T777 Q4VBZ0 Q86VX5 Q9H2J3 Q969G8 Q96A46 |
Accessions | EAW49863 EAW49864 EAW49865 EAW49866 Q96A46 AF267854 AAG44723 AF327402 AAK49519 AF327403 AAK49520 AJ303077 CAC27996 AJ303078 CAC27997 AK056782 AK094405 AL831943 CAH10774 BC015951 BC047312 AAH47312 BC058937 AAH58937 BC064541 BC076399 AAH76399 BC094821 AAH94821 CD672723 HG503197 XM_005270208 XP_005270265 XM_005270209 XP_005270266 XM_005270211 XP_005270268 XM_006718005 XP_006718068 XM_006718006 XP_006718069 XM_011540239 XP_011538541 XM_011540240 XP_011538542 XM_011540241 XP_011538543 XM_011540242 XP_011538544 XM_011540243 XP_011538545 XM_011540244 XP_011538546 XR_945826 NM_031212 NP_112489 |
Function | Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11297739}; Multi-pass membrane protein {ECO:0000269|PubMed:11297739}. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion. |
Tissue Specificity | Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO:0000269|PubMed:11297739}. |
Mitoferrin 2 CRISPR/Cas9 KO Plasmid (h) - sc-405916 from Santa Cruz Biotechnology
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Mitoferrin 2 HDR Plasmid (h) - sc-405916-HDR from Santa Cruz Biotechnology
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Mitoferrin 2 Double Nickase Plasmid (h) - sc-405916-NIC from Santa Cruz Biotechnology
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Mitoferrin 2 Double Nickase Plasmid (h2) - sc-405916-NIC-2 from Santa Cruz Biotechnology
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Mitoferrin 2 CRISPR Activation Plasmid (h) - sc-405916-ACT from Santa Cruz Biotechnology
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Mitoferrin 2 CRISPR Activation Plasmid (h2) - sc-405916-ACT-2 from Santa Cruz Biotechnology
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Mitoferrin 2 Lentiviral Activation Particles (h) - sc-405916-LAC from Santa Cruz Biotechnology
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Mitoferrin 2 Lentiviral Activation Particles (h2) - sc-405916-LAC-2 from Santa Cruz Biotechnology
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Mitoferrin 2 siRNA (h) - sc-90800 from Santa Cruz Biotechnology
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Mitoferrin 2 shRNA Plasmid (h) - sc-90800-SH from Santa Cruz Biotechnology
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Mitoferrin 2 shRNA (h) Lentiviral Particles - sc-90800-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19497 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19497 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02268 from Sigma-Aldrich
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SLC25A28 siRNA (Human) - CRJ3082 from Cohesion Biosciences
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SLC25A28 - MBS8218556 from MyBioSource
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shRNA set against Human SLC25A28 (NM_031212.3) - SHH409620 from Creative biogene
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shRNA set against Human SLC25A28(NM_031212.3) - SHL003216 from Creative biogene
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Human SLC25A28 siRNA - orb273583 from Biorbyt
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SLC25A28 shRNA Plasmid (Human) - CHJ3082 from Cohesion Biosciences
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SLC25A28 miRNA 3'UTR clone - MiUTR3H-10791 from Creative biogene
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