Gene Symbol | SLC25A28 |
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Entrez Gene | 81894 |
Alt Symbol | MFRN2, MRS3/4, MRS4L, NPD016 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25 (mitochondrial iron transporter), member 28 |
Other Description | hMRS3/4|mitochondrial RNA splicing protein 3/4|mitochondrial RNA-splicing protein 3/4 homolog|mitochondrial iron transporter 2|mitoferrin 2|mitoferrin-2|putative mitochondrial solute carrier|solute carrier family 25, member 28 |
Swissprots | Q5T777 Q4VBZ0 Q86VX5 Q9H2J3 Q969G8 Q96A46 |
Accessions | EAW49863 EAW49864 EAW49865 EAW49866 Q96A46 AF267854 AAG44723 AF327402 AAK49519 AF327403 AAK49520 AJ303077 CAC27996 AJ303078 CAC27997 AK056782 AK094405 AL831943 CAH10774 BC015951 BC047312 AAH47312 BC058937 AAH58937 BC064541 BC076399 AAH76399 BC094821 AAH94821 CD672723 HG503197 XM_005270208 XP_005270265 XM_005270209 XP_005270266 XM_005270211 XP_005270268 XM_006718005 XP_006718068 XM_006718006 XP_006718069 XM_011540239 XP_011538541 XM_011540240 XP_011538542 XM_011540241 XP_011538543 XM_011540242 XP_011538544 XM_011540243 XP_011538545 XM_011540244 XP_011538546 XR_945826 NM_031212 NP_112489 |
Function | Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11297739}; Multi-pass membrane protein {ECO:0000269|PubMed:11297739}. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion. |
Tissue Specificity | Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO:0000269|PubMed:11297739}. |
Mitoferrin 2 (P-12) - sc-138430 from Santa Cruz Biotechnology
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Anti-SLC25A28 antibody - ab103758 from Abcam
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Anti-SLC25A28 Antibody (aa44-74, AP) - LS-C207232 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74, APC) - LS-C207233 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74, Azide-free, HRP) - LS-C207236 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74, FITC) - LS-C207235 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74, Biotin) - LS-C207234 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74, PE) - LS-C207237 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa44-74) - LS-C322982 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa215-264) - LS-C110855 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa36-64) - LS-C164163 from LifeSpan Bioscience
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Anti-SLC25A28 Antibody (aa290-339) IHC-plus⢠- LS-B3556 from LifeSpan Bioscience
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SLC25A28 Antibody - NBP1-59562 from Novus Biologicals
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SLC25A28 Antibody - NBP1-59567 from Novus Biologicals
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SLC25A28 Antibody - NBP2-20390 from Novus Biologicals
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Mitoferrin 2 Polyclonal Antibody - bs-7157R from Bioss
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Anti-SLC25A28 antibody produced in rabbit - AV44054 from Sigma-Aldrich
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ANTI-MFRN2(N-TERMINAL) antibody produced in rabbit - SAB1306500 from Sigma-Aldrich
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Anti-SLC25A28 antibody produced in rabbit - SAB2103809 from Sigma-Aldrich
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SLC25A28 antibody - middle region (ARP44053_P050) - ARP44053_P050 from Aviva Systems Biology
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SLC25A28 antibody - C-terminal region (ARP44054_P050) - ARP44054_P050 from Aviva Systems Biology
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MFRN2 Antibody - N-terminal region (OAAB02661) - OAAB02661 from Aviva Systems Biology
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MFRN2-Antibody-N-term - AP5244a from Abgent, a WuXi AppTec company
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SLC25A28 antibody - 70R-6475 from Fitzgerald
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Anti -MFRN2, NT (SLC25A28, MFRN2, Mitoferrin-2, Mitochondrial RNA-splicing protein 3/4homolog, Mitochondrial iron transporter 2, Solute carrier family 25 member 28) - 038400 from USBiological Life Science
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