RICTOR

Gene Symbol	RICTOR
Entrez Gene	253260
Alt Symbol	AVO3, PIA, hAVO3
Species	Human
Gene Type	protein-coding
Description	RPTOR independent companion of MTOR, complex 2
Other Description	AVO3 homolog|TORC2-specific protein AVO3|pianissimo|rapamycin-insensitive companion of mTOR
Swissprots	Q8N3A0 Q86UB7 B2RNX0 Q6R327 Q68DT5 B7ZMF7 Q8NCM6
Accessions	EAW55978 EAW55979 EAW55980 Q6R327 AB082530 BAC02708 AK024327 AK094538 AK127305 AK128358 AL834497 CAD39155 AY515854 AAS79796 BC029608 AAH29608 BC051729 AAH51729 BC137163 AAI37164 BC137164 AAI37165 BC144509 AAI44510 BP245264 CN478622 CR749280 CAH18135 DQ891672 ABM82598 DQ894858 ABM85784 XM_006714463 XP_006714526 XM_011514005 XP_011512307 XM_011514006 XP_011512308 XM_011514007 XP_011512309 NM_001285439 NP_001272368 NM_001285440 NP_001272369 NM_152756 NP_689969
Function	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470}.
Top Pathways	mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RICTOR protein fragment - ab112435 from Abcam Category Protein Source Wheat germ Species Human

RICTOR peptide (1698-1708) - ab45725 from Abcam Category Peptide Species Human

RICTOR Antibody Blocking Peptide - LS-E8807 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RICTOR Antibody Blocking Peptide - LS-E8808 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RICTOR Antibody Blocking Peptide - LS-E25866 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rictor Protein - H00253260-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RICTOR-Antibody-N-term-Blocking-Peptide - BP7259d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rictor-Antibody-N-term-Blocking-Peptide - BP7259a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RICTOR blocking peptide - GTX89552-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

Rictor Blocking Peptide - 33R-11028 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

Rictor Peptide - AC21-0696-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RICTOR - H00253260-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RICTOR - H00253260-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RICTOR Peptide - 46-299P from ProSci Category Peptide Species Human

RICTOR fusion protein - ag3598 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RICTOR - RICTOR-31328TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Rapamycin-insensitive companion of mTOR(RICTOR) ,partial - CSB-YP761396HU CSB-EP761396HU CSB-BP761396HU CSB-MP761396HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Rictor Blocking Peptide - 3957BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

RICTOR Protein - abx164015 from Abbexa Category Protein Species Human, Mouse

RICTOR, Peptide - MBS426928 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog

RICTOR fusion protein - Ag25248 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Rictor Protein - NBP1-88916PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Rictor Recombinant Protein Antigen - NBP2-38365PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RICTOR-Antibody-Center-Blocking-Peptide - BP7259c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RICTOR-Antibody-C-term-Blocking-Peptide - BP7259b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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