RICTOR

Gene Symbol RICTOR
Entrez Gene 253260
Alt Symbol AVO3, PIA, hAVO3
Species Human
Gene Type protein-coding
Description RPTOR independent companion of MTOR, complex 2
Other Description AVO3 homolog|TORC2-specific protein AVO3|pianissimo|rapamycin-insensitive companion of mTOR
Swissprots Q8N3A0 Q86UB7 B2RNX0 Q6R327 Q68DT5 B7ZMF7 Q8NCM6
Accessions EAW55978 EAW55979 EAW55980 Q6R327 AB082530 BAC02708 AK024327 AK094538 AK127305 AK128358 AL834497 CAD39155 AY515854 AAS79796 BC029608 AAH29608 BC051729 AAH51729 BC137163 AAI37164 BC137164 AAI37165 BC144509 AAI44510 BP245264 CN478622 CR749280 CAH18135 DQ891672 ABM82598 DQ894858 ABM85784 XM_006714463 XP_006714526 XM_011514005 XP_011512307 XM_011514006 XP_011512308 XM_011514007 XP_011512309 NM_001285439 NP_001272368 NM_001285440 NP_001272369 NM_152756 NP_689969
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470}.
Top Pathways mTOR signaling pathway

Phospho-Rictor (Thr1135) (D30A3) Rabbit mAb - 3806 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D30A3
Western blot analysis of extracts from serum-starved HeLa cells, untreated or treated with IGF-1 (50 ng/ml, 30 minutes) and λ phosphatase, using Phospho-Rictor (Thr1135) (D30A3) Rabbit mAb (upper) or Rictor (53A2) Rabbit mAb #2114 (lower).

Rictor Antibody - 2140 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using Rictor Antibody.

Rictor (53A2) Rabbit mAb - 2114 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 53A2
Western blot analysis of extracts from various cell lines, using Rictor (53A2) Rabbit mAb.

Rictor (D16H9) Rabbit mAb - 9476 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D16H9
Western blot analysis of extracts from RD and HeLa cells using Rictor (D16H9) Rabbit mAb.

Rictor (H-11) - sc-271081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rictor (H-11): sc-271081. Western blot analysis of Rictor expression in Ramos (A), MDCK (B), NIH/3T3 (C) and PC-12 (D) whole cell lysates.

Rictor (H-278) - sc-99004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rictor (H-278): sc-99004. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and nuclear staining of cells in glomeruli and cells in tubules.

Rictor (S-20) - sc-50678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rictor (S-20): sc-50678. Western blot analysis of Rictor expression in 293T whole cell lysate.

Rictor (1G11) - sc-81538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Rictor (1G11): sc-81538. Western blot analysis of Rictor expression in Ramos whole cell lysate.

Rictor (V-23) - sc-130865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Rictor (V-23): sc-130865. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing cytoplasmic localization.

Anti-RICTOR antibody - ab56578 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-RICTOR antibody (ab56578) at 1 µg/ml + Immunogen recombinant fragment 1-99aaObserved band size : 36.52 kDa (why is the actual band size different from the predicted?)

Anti-RICTOR antibody - ab70373 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RICTOR antibody (ab70373) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

Anti-RICTOR antibody - ab96687 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-RICTOR antibody (ab96687) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-RICTOR antibody - ab63052 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab63052, at a 1/50 dilution, staining RICTOR in formalin fixed, paraffin embedded human lymph tissue by Immunohistochemistry. ab63052 was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-RICTOR antibody - ab79984 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab79984, at a 1/10 dilution, staining RICTOR in formalin fixed, paraffin embedded human testis tissue by Immunohistochemistry. ab79984 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-RICTOR antibody - ab117089 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Renal Tubular Epithelium tissue (formalin-fixed, paraffin-embedded) stained with ab117089 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-RICTOR antibody [1F3] - ab128042 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1F3
Anti-RICTOR antibody [1F3] (ab128042) at 1/500 dilution + HeLa nuclear extract

Anti-RICTOR antibody [7B3] - ab104838 from Abcam

Prices $388.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B3
All lanes : Anti-RICTOR antibody [7B3] (ab104838) at 1/500 dilutionLane 1 : HeLa cell lysate.Lane 2 : PANC-1 cell lysate.Lane 3 : MOLT4 cell lysate.Lane 4 : HepG2 cell lysate.Lane 5 : HEK293 cell lysate.

Anti-RICTOR Antibody (C-Terminus) - LS-C93300 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RICTOR Antibody - LS-C131923 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RICTOR Antibody - LS-C131924 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-RICTOR Antibody - LS-C147069 from LifeSpan Bioscience

Prices $410.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-RICTOR Antibody (aa270-283) - LS-C148015 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-RICTOR Antibody (aa1-50) - LS-C19387 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Rictor in Jurkat cell lysate using antibody at 7 ug/ml.

Anti-RICTOR Antibody (aa856-871) - LS-C148016 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-RICTOR Antibody (aa1505-1520) - LS-C148063 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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