| Gene Symbol |
ATG16L1
|
| Entrez Gene |
55054
|
| Alt Symbol |
APG16L, ATG16A, ATG16L, IBD10, WDR30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 16-like 1 (S. cerevisiae)
|
| Other Description |
APG16L beta|ATG16 autophagy related 16-like 1|WD repeat domain 30|autophagy-related protein 16-1
|
| Swissprots |
Q6UXW4 A3EXL0 A3EXK9 Q6IPN1 Q6ZVZ5 Q8NCY2 Q9H619 B6ZDH0 Q96JV5 Q676U5
|
| Accessions |
AAY14860 BAJ13474 BAJ13475 EAW71033 EAW71034 EAW71035 EAW71036 EAW71037 EAW71038 EAW71039 EAW71040 Q676U5 AA809053 AK000897 BAA91413 AK001690 AK024453 BAB15743 AK026330 BAB15448 AK027854 BAB55412 AK074434 BAB85082 AK123876 BAC85713 AK308400 AL834526 CAD39182 AY358182 AAQ88549 AY398617 AAR32130 BC000061 BC006253 BC013411 BC071846 AAH71846 BC117337 AAI17338 BC143900 AAI43901 BG702756 DB084962 DB474638 EF079889 ABN48554 EF079890 ABN48555 EF560734 ABQ59044 JQ924062 AGC52704 XM_005246082 XP_005246139 XM_005246084 XP_005246141 XM_005246086 XP_005246143 XM_006712608 XP_006712671 XM_011548853 XP_011547155 XM_011548854 XP_011547156 XM_011548855 XP_011547157 XM_011548856 XP_011547158 XR_241242 XR_953240 NM_001190266 NP_001177195 NM_001190267 NP_001177196 NM_017974 NP_060444 NM_030803 NP_110430 NM_198890 NP_942593
|
| Function |
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250|UniProtKB:Q8C0J2}.
|
| Top Pathways |
Regulation of autophagy
|
![Western Blot: ATG16L1 Overexpression Lysate (Adult Normal) [NBP2-06180] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ATG16L1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6620_ATG16L1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06180-img0001.jpg)