ATG16L1

Gene Symbol ATG16L1
Entrez Gene 55054
Alt Symbol APG16L, ATG16A, ATG16L, IBD10, WDR30
Species Human
Gene Type protein-coding
Description autophagy related 16-like 1 (S. cerevisiae)
Other Description APG16L beta|ATG16 autophagy related 16-like 1|WD repeat domain 30|autophagy-related protein 16-1
Swissprots Q6UXW4 A3EXL0 A3EXK9 Q6IPN1 Q6ZVZ5 Q8NCY2 Q9H619 B6ZDH0 Q96JV5 Q676U5
Accessions AAY14860 BAJ13474 BAJ13475 EAW71033 EAW71034 EAW71035 EAW71036 EAW71037 EAW71038 EAW71039 EAW71040 Q676U5 AA809053 AK000897 BAA91413 AK001690 AK024453 BAB15743 AK026330 BAB15448 AK027854 BAB55412 AK074434 BAB85082 AK123876 BAC85713 AK308400 AL834526 CAD39182 AY358182 AAQ88549 AY398617 AAR32130 BC000061 BC006253 BC013411 BC071846 AAH71846 BC117337 AAI17338 BC143900 AAI43901 BG702756 DB084962 DB474638 EF079889 ABN48554 EF079890 ABN48555 EF560734 ABQ59044 JQ924062 AGC52704 XM_005246082 XP_005246139 XM_005246084 XP_005246141 XM_005246086 XP_005246143 XM_006712608 XP_006712671 XM_011548853 XP_011547155 XM_011548854 XP_011547156 XM_011548855 XP_011547157 XM_011548856 XP_011547158 XR_241242 XR_953240 NM_001190266 NP_001177195 NM_001190267 NP_001177196 NM_017974 NP_060444 NM_030803 NP_110430 NM_198890 NP_942593
Function Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904}.
Subcellular Location Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250|UniProtKB:Q8C0J2}.
Top Pathways Regulation of autophagy

Atg16L1 (D6D5) Rabbit mAb - 8089 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6D5
Western blot analysis of extracts from various cell lines using Atg16L1 (D6D5) Rabbit mAb.

Atg16 (C-20) - sc-70133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Atg16 (C-20): sc-70133. Western blot analysis of Atg16 expression in mouse brain tissue extract.

Atg16 (D-15) - sc-70134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ATG16L1 antibody - ab47946 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ATG16L1 was immunoprecipitated using 0.5mg Mouse Lung tissue, 5µg of Rabbit polyclonal to ATG16L1 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, Mouse Lung tissue lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab47946.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 57kDa; ATG16L1

Anti-ATG16L1 antibody - ab188642 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue sections labeling ATG16L1 using ab188642 at 5 µg/ml.

Anti-ATG16L1 antibody - ab106354 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-ATG16L1 antibody (ab106354) at 0.25 µg/mlLane 2 : Anti-ATG16L1 antibody (ab106354) at 0.5 µg/mlLane 1 : HeLa Cell lysateLane 2 : HeLa Cell lysateLysates/proteins at 15 µg per lane.

Anti-ATG16L1 antibody - ab64778 from Abcam

Host Sheep
Clonality Polyclonal

Anti-ATG16L1 antibody - ab176601 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATG16L1 antibody (ab176601) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : A549 cell lysateLane 3 : MCF-7 cell lysateLane 4 : Human fetal lung lysate

Anti-ATG16L1 antibody - ab90442 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ATG16L1 antibody (ab90442) at 1 µg/ml + Human placenta tissue lysate at 50 µg

Anti-ATG16L1 antibody - ab117816 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Human ATG16L1 in Immunoprecipitates of Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells using ab117816 at 6 µg/mg of lysate (Lane 1). Lane 2 is the IgG immunoprecipitate control. Subsequent WB detection was done using an other anti Human ATG16L1 antibody.

Anti-ATG16L1 antibody [EPR15638] - N-terminal - ab187671 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15638
Immunohistochemical analysis of paraffin-embedded Human prostatic hyperplasia tissue labeling ATG16L1 with ab187671 at 1/100 dilution followed by pre-diluted HRP Polymer for Rabbit IgG secondary antibody and counter-stained with Hematoxylin.

Anti-ATG16L1 antibody - N-terminal - ab188649 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling ATG16L1 with ab188649 at 5 µg/ml.

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY650) - LS-C141400 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY488) - LS-C141401 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, HRP) - LS-C141402 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY550) - LS-C141403 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa215-264) - LS-C111549 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATG16L1 antibody LS-C111549 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.

Anti-ATG16L1 / ATG16L Antibody (aa1-100, Biotin) - LS-C141694 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa121-170) - LS-C116867 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATG16L1 antibody LS-C116867 Western blot of Jurkat lysate.

Anti-ATG16L1 / ATG16L Antibody (aa81-130) - LS-C117029 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATG16L1 antibody LS-C117029 Western blot of Jurkat lysate.

Anti-ATG16L1 / ATG16L Antibody (aa1-100, Biotin) - LS-C141868 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY650) - LS-C141869 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, HRP) - LS-C141871 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY488) - LS-C141870 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG16L1 / ATG16L Antibody (aa1-100, DY550) - LS-C141872 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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