| Gene Symbol |
Fgf2
|
| Entrez Gene |
54250
|
| Alt Symbol |
Fgf-2, bFGF
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
fibroblast growth factor 2
|
| Other Description |
HBGF-2|basic fibroblast growth factor|heparin-binding growth factor 2
|
| Swissprots |
P13109
|
| Accessions |
AAC53225 EDM01301 EDM01302 EDM01303 EDM01304 P13109 M22427 AAA41210 X07285 CAA30265 NM_019305 NP_062178
|
| Function |
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Nucleus {ECO:0000250}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Found in all tissues examined.
|
| Top Pathways |
Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway
|