NOS1

Gene Symbol	NOS1
Entrez Gene	4842
Alt Symbol	IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Species	Human
Gene Type	protein-coding
Description	nitric oxide synthase 1 (neuronal)
Other Description	NOS type I|constitutive NOS|neuronal NOS|nitric oxide synthase, brain|peptidyl-cysteine S-nitrosylase NOS1
Swissprots	O75713 E9PH30 P29475
Accessions	AAB60654 AAR07069 CCQ42990 EAW98108 EAW98109 EAW98110 P29475 AF446131 AF446132 AF446133 AF446134 AF446135 AF446136 AF446137 AF446138 AF446139 AF446140 AJ004918 CAA06218 AK294435 BAG57679 AK307481 BC010126 BC033208 AAH33208 BC156399 AAI56400 BC172474 AAI72474 BE207961 D16408 BAA03895 EU753241 ACF04132 L02881 AAA36376 U17327 AAA62405 U31466 AAB49040 XM_011538398 XP_011536700 NM_000620 NP_000611 NM_001204213 NP_001191142 NM_001204214 NP_001191143 NM_001204218 NP_001191147
Function	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Subcellular Location	Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
Top Pathways	Circadian entrainment, Phagosome, Salivary secretion, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active rat nNOS (neuronal) full length protein - ab157270 from Abcam Category Protein Prices $192.00 Sizes 50 µl Source Baculovirus infected sf9 cells Species Rat

Active rat nNOS (neuronal) full length protein - ab59110 from Abcam Category Protein Prices $363.00 Sizes 5 units Source Baculovirus infected sf9 cells Species Rat

Human nNOS (neuronal) (phospho S1417) peptide - ab41773 from Abcam Category Peptide Species Human

Human nNOS (neuronal) peptide - ab22863 from Abcam Category Peptide Species Human

Human nNOS (neuronal) protein fragment - ab159005 from Abcam Category Protein Source Wheat germ Species Human

Mouse nNOS (neuronal) (phospho S847) peptide - ab16981 from Abcam Category Peptide Source CHO

nNOS (neuronal) peptide - ab5891 from Abcam Category Peptide

Phospho-nNOSS1417-Antibody-Blocking-peptide - BP3677a from Abgent, a WuXi AppTec company Category Peptide Prices $69.00 Sizes 100 µg

nNOS blocking peptide - GTX89962-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human NOS1 Protein - abx068295 from Abbexa Category Protein Source E.coli Species Human

nNOS Blocking Peptide - abx063010 from Abbexa Category Peptide Species Human, Mouse, Rat

nNOS Peptide - AC21-0105-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NOS1 - H00004842-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NOS1 - H00004842-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NOS1 control peptide - SP5115CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

NOS1 Control Peptide - SP5116CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

NOS1 Control Peptide - 24337 from Acris Antibodies Category Peptide Prices $135.00 Sizes 25 µg

NOS1 control peptide - 24447 from Acris Antibodies Category Peptide Prices $135.00 Sizes 25 µg

Nitric Oxide Synthase 1, Neuronal (NOS1), Human - 20-7150 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

NOS1 Peptide - 45-098P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

Recombinant Human NOS1 - NOS1-299H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Nitric Oxide Synthase 1 (Neuronal) - NOS1-612H from Creative Biomart Category Protein Source E.coli.

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1) - RPA815Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1) - RPA815Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Nitric Oxide Synthase 1, Neuronal (NOS1) - RPA815Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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