| Gene Symbol | CHRM2 |
|---|---|
| Entrez Gene | 1129 |
| Alt Symbol | HM2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholinergic receptor, muscarinic 2 |
| Other Description | 7TM receptor|acetylcholine receptor, muscarinic 2|muscarinic M2 receptor|muscarinic acetylcholine receptor M2 |
| Swissprots | Q9P1X9 Q4VBK6 P08172 |
| Accessions | AAA51570 BAA94476 CAA33335 CBJ06536 EAL24054 EAW83865 EAW83866 P08172 AF385588 AAK68113 AF498916 AAM18939 AK125233 AK290236 BAF82925 AL832585 AM393517 CAL38394 AY034603 AAO23567 AY034604 AAO23568 AY034605 AAO23569 AY219703 AAO65595 AY219704 AAO65596 AY219705 AAO65597 AY456125 AAR14890 AY456126 AAR14891 AY456127 AAR14892 AY456128 AAR14893 AY456129 AAR14894 BC095547 AAH95547 BC106741 AAI06742 BC106742 AAI06743 XM_011515769 XP_011514071 XM_011515770 XP_011514072 XM_011515771 XP_011514073 NM_000739 NP_000730 NM_001006626 NP_001006627 NM_001006627 NP_001006628 NM_001006628 NP_001006629 NM_001006629 NP_001006630 NM_001006630 NP_001006631 NM_001006631 NP_001006632 NM_001006632 NP_001006633 NM_001006633 |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}. |
| Top Pathways | Calcium signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction |