CHRM2

Gene Symbol CHRM2
Entrez Gene 1129
Alt Symbol HM2
Species Human
Gene Type protein-coding
Description cholinergic receptor, muscarinic 2
Other Description 7TM receptor|acetylcholine receptor, muscarinic 2|muscarinic M2 receptor|muscarinic acetylcholine receptor M2
Swissprots Q9P1X9 Q4VBK6 P08172
Accessions AAA51570 BAA94476 CAA33335 CBJ06536 EAL24054 EAW83865 EAW83866 P08172 AF385588 AAK68113 AF498916 AAM18939 AK125233 AK290236 BAF82925 AL832585 AM393517 CAL38394 AY034603 AAO23567 AY034604 AAO23568 AY034605 AAO23569 AY219703 AAO65595 AY219704 AAO65596 AY219705 AAO65597 AY456125 AAR14890 AY456126 AAR14891 AY456127 AAR14892 AY456128 AAR14893 AY456129 AAR14894 BC095547 AAH95547 BC106741 AAI06742 BC106742 AAI06743 XM_011515769 XP_011514071 XM_011515770 XP_011514072 XM_011515771 XP_011514073 NM_000739 NP_000730 NM_001006626 NP_001006627 NM_001006627 NP_001006628 NM_001006628 NP_001006629 NM_001006629 NP_001006630 NM_001006630 NP_001006631 NM_001006631 NP_001006632 NM_001006632 NP_001006633 NM_001006633
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}.
Top Pathways Calcium signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

mAChR M2 CRISPR/Cas9 KO Plasmid (h) - sc-402394 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 HDR Plasmid (h) - sc-402394-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 Double Nickase Plasmid (h) - sc-402394-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 Double Nickase Plasmid (h2) - sc-402394-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 CRISPR Activation Plasmid (h) - sc-402394-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 CRISPR Activation Plasmid (h2) - sc-402394-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 Lentiviral Activation Particles (h) - sc-402394-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 Lentiviral Activation Particles (h2) - sc-402394-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mAChR M2 siRNA (h) - sc-35831 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mAChR M2 shRNA Plasmid (h) - sc-35831-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mAChR M2 shRNA (h) Lentiviral Particles - sc-35831-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R15 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R18 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R16 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R14 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R13 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R12 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120771 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6092 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6092 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHRM2 siRNA (Human) - CRH0806 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R10 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R11 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Muscarinic Acetylcholine Receptor M2/CHRM2 RNAi - H00001129-R17 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CHRM2 - MBS829464 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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