CHRM2

Gene Symbol CHRM2
Entrez Gene 1129
Alt Symbol HM2
Species Human
Gene Type protein-coding
Description cholinergic receptor, muscarinic 2
Other Description 7TM receptor|acetylcholine receptor, muscarinic 2|muscarinic M2 receptor|muscarinic acetylcholine receptor M2
Swissprots Q9P1X9 Q4VBK6 P08172
Accessions AAA51570 BAA94476 CAA33335 CBJ06536 EAL24054 EAW83865 EAW83866 P08172 AF385588 AAK68113 AF498916 AAM18939 AK125233 AK290236 BAF82925 AL832585 AM393517 CAL38394 AY034603 AAO23567 AY034604 AAO23568 AY034605 AAO23569 AY219703 AAO65595 AY219704 AAO65596 AY219705 AAO65597 AY456125 AAR14890 AY456126 AAR14891 AY456127 AAR14892 AY456128 AAR14893 AY456129 AAR14894 BC095547 AAH95547 BC106741 AAI06742 BC106742 AAI06743 XM_011515769 XP_011514071 XM_011515770 XP_011514072 XM_011515771 XP_011514073 NM_000739 NP_000730 NM_001006626 NP_001006627 NM_001006627 NP_001006628 NM_001006628 NP_001006629 NM_001006629 NP_001006630 NM_001006630 NP_001006631 NM_001006631 NP_001006632 NM_001006632 NP_001006633 NM_001006633
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}.
Top Pathways Calcium signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

mAChR M2 (H-170) - sc-9107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mAChR M2 (H-170): sc-9107. Western blot analysis of human recombinant mAChR M2 fusion protein.

mAChR M2 (C-18) - sc-7472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mAChR M2 (C-18): sc-7472. Western blot analysis of mAChR M2 expression in MCF7 (A), Jurkat (B), IMR-32 (C) and K-562 (D) whole cell lysates.

mAChR M2 (K-18) - sc-31483 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mAChR M2 (M2-2-B3) - sc-33712 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
mAChR M2 (M2-2-B3): sc-33712. Western blot analysis of human recombinant mAChR M2 fusion protein.

mAChR M2 (T-19) - sc-31485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

mAChR M2 (31-3B7) - sc-80971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

mAChR M2 (2Q147) - sc-71531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal

Anti-Muscarinic Acetylcholine Receptor 2 antibody - ab123421 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Muscarinic Acetylcholine Receptor 2 antibody (ab123421) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-Muscarinic Acetylcholine Receptor 2 antibody - ab136041 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Muscarinic Acetylcholine Receptor 2 antibody (ab136041) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-Muscarinic Acetylcholine Receptor 2 antibody [31-1D1] - ab2805 from Abcam

Prices $391.00
Sizes 125 µl
Host Mouse
Clonality Monoclonal
Clone 31-1D1
Immunohistochemistry was performed on normal biopsies of deparaffinized human kidney tissue. To expose target proteins heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer and microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:20 with a Mouse monoclonal antibody recognizing Muscarinic Acetylcholine Receptor 2 (ab2805) or without primary antibody (negative control) overnight at 4�C in a humidified chamber. Tissues were washed extensively with PBST and endogenous peroxidase activity was quenched with a peroxidase suppressor. Detection was performed using a biotin-conjugated secondary antibody and SA-HRP followed by colorimetric detection using DAB. Tissues were counterstained with hematoxylin and prepped for mounting.

Anti-Muscarinic Acetylcholine Receptor 2 antibody [EPR4568] - ab109226 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4568
All lanes : Anti-Muscarinic Acetylcholine Receptor 2 antibody [EPR4568] (ab109226) at 1/1000 dilutionLane 1 : SH-SY5Y lysateLane 2 : Fetal brain lysateLane 3 : U87-MG lysateLane 4 : Neuro-2a lysateLane 5 : Y79 lysates Lysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1331 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CHRM2 / M2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1333 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CHRM2 / M2 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CHRM2 / M2 Antibody (aa225-359) - LS-C9134 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-CHRM2 / M2 Antibody (aa457-466) - LS-C9133 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRM2 / M2 Antibody (C-Terminus) - LS-C37393 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRM2 / M2 Antibody - LS-C72918 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CHRM2 / M2 Antibody (C-Terminus) - LS-C37394 from LifeSpan Bioscience

Prices $435.00
Sizes 5 ml
Host Rabbit
Clonality Polyclonal

Anti-CHRM2 / M2 Antibody (aa251-351) - LS-C125966 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CHRM2 / M2 Antibody (aa168-192, clone B8E5) - LS-C124189 from LifeSpan Bioscience

Prices $620.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B8E5

Anti-CHRM2 / M2 Antibody (aa168-192, clone B8E5) - LS-C140139 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B8E5

Anti-CHRM2 / M2 Antibody - LS-C144025 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CHRM2 / M2 Antibody (aa451-466, Sepharose) - LS-C172131 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1330 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CHRM2 antibody LS-A1330 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CHRM2 / M2 Antibody (clone 2-1-155) - LS-C180186 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 2-1-155
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