| Gene Symbol |
OS9
|
| Entrez Gene |
10956
|
| Alt Symbol |
ERLEC2, OS-9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
osteosarcoma amplified 9, endoplasmic reticulum lectin
|
| Other Description |
amplified in osteosarcoma 9|endoplasmic reticulum lectin 2|erlectin 2|osteosarcoma amplified 9, endoplasmic reticulum associated protein|protein OS-9
|
| Swissprots |
A8K5Q9 E7ENT8 B4DE28 A6NDD1 Q8IZ58 B4E1I6 A6NLB2 A6NFR7 Q6IBL2 B4DPX1 G3XA88 O00579 F8VUH2 Q13438 Q9BW99 E7EW91
|
| Accessions |
AAC39523 BAA24362 EAW97044 EAW97045 EAW97046 EAW97047 Q13438 AB002806 BAA24363 AK129781 AK130733 AK291374 BAF84063 AK293435 BAG56939 AK294870 BAG57972 AK296770 BAG59349 AK298532 BAG60733 AK303291 BAH13933 AK303858 BAG64798 AK304533 BAG65333 AL137691 AU132426 BC000532 AAH00532 BC006506 AAH06506 BC007254 AAH07254 BC023513 AAH23513 BQ954079 CN335053 CR456791 CAG33072 DQ892759 ABM83685 DQ896004 ABM86982 EF036505 ABO65091 U09408 U41635 AAB06495 XM_005268581 XP_005268638 XM_006719200 XP_006719263 XM_006719201 XP_006719264 NM_001017956 NP_001017956 NM_001017957 NP_001017957 NM_001017958 NP_001017958 NM_001261420 NP_001248349 NM_001261421 NP_001248350 NM_001261422 NP_001248351 NM_001261423 NP_001248352 NM_006812 NP_006803
|
| Function |
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. {ECO:0000269|PubMed:17932042, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021, ECO:0000269|PubMed:19346256, ECO:0000269|PubMed:21172656}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021}.
|
| Tissue Specificity |
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|