OS9

Gene Symbol	OS9
Entrez Gene	10956
Alt Symbol	ERLEC2, OS-9
Species	Human
Gene Type	protein-coding
Description	osteosarcoma amplified 9, endoplasmic reticulum lectin
Other Description	amplified in osteosarcoma 9|endoplasmic reticulum lectin 2|erlectin 2|osteosarcoma amplified 9, endoplasmic reticulum associated protein|protein OS-9
Swissprots	A8K5Q9 E7ENT8 B4DE28 A6NDD1 Q8IZ58 B4E1I6 A6NLB2 A6NFR7 Q6IBL2 B4DPX1 G3XA88 O00579 F8VUH2 Q13438 Q9BW99 E7EW91
Accessions	AAC39523 BAA24362 EAW97044 EAW97045 EAW97046 EAW97047 Q13438 AB002806 BAA24363 AK129781 AK130733 AK291374 BAF84063 AK293435 BAG56939 AK294870 BAG57972 AK296770 BAG59349 AK298532 BAG60733 AK303291 BAH13933 AK303858 BAG64798 AK304533 BAG65333 AL137691 AU132426 BC000532 AAH00532 BC006506 AAH06506 BC007254 AAH07254 BC023513 AAH23513 BQ954079 CN335053 CR456791 CAG33072 DQ892759 ABM83685 DQ896004 ABM86982 EF036505 ABO65091 U09408 U41635 AAB06495 XM_005268581 XP_005268638 XM_006719200 XP_006719263 XM_006719201 XP_006719264 NM_001017956 NP_001017956 NM_001017957 NP_001017957 NM_001017958 NP_001017958 NM_001261420 NP_001248349 NM_001261421 NP_001248350 NM_001261422 NP_001248351 NM_001261423 NP_001248352 NM_006812 NP_006803
Function	Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. {ECO:0000269|PubMed:17932042, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021, ECO:0000269|PubMed:19346256, ECO:0000269|PubMed:21172656}.
Subcellular Location	Endoplasmic reticulum lumen {ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021}.
Tissue Specificity	Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OS-9 (D8P4G) Rabbit mAb - 12497 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D8P4G

OS-9 (D-17) - sc-168853 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

OS-9 (G-15) - sc-168854 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-OS9 antibody - ab19853 from Abcam Prices $398.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OS9 antibody - ab130722 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-OS9 antibody [EPR4272(2)] - ab109510 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4272(2)

Anti-OS9 Antibody (C-Terminus) - LS-C73933 from LifeSpan Bioscience Prices $455.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (Internal, DY650) - LS-C141206 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (Internal, Biotin) - LS-C141205 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (Internal, HRP) - LS-C141208 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (Internal, DY488) - LS-C141207 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (Internal, DY550) - LS-C141209 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa521-549, AP) - LS-C265241 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa521-549, APC) - LS-C265242 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa521-549, FITC) - LS-C265243 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa521-549, PE) - LS-C265244 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa520-549) - LS-C323694 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (C-Terminus) - LS-C187163 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (aa521-549) - LS-C158505 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-OS9 Antibody (C-Terminus, clone EPR4272(2)) - LS-C138474 from LifeSpan Bioscience Prices $480.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4272(2)

Anti-OS9 Antibody (aa300-400) IHC-plus™ - LS-B10208 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

OS9 Antibody - NB100-519 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

OS9 Antibody - BC100-520 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

OS9 Antibody - NBP1-84803 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

OS9 Antibody - H00010956-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

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