CDC14A
| Gene Symbol | CDC14A |
|---|---|
| Entrez Gene | 8556 |
| Alt Symbol | cdc14, hCDC14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 14A |
| Other Description | CDC10 (cell division cycle 10, S. cerevisiae, homolog)|CDC14 cell division cycle 14 homolog A|dual specificity protein phosphatase CDC14A |
| Swissprots | O43171 O60728 B1AQ15 Q8IXX0 O60727 Q9UNH5 B1AQ14 A6MA65 Q52LH9 |
| Accessions | AAT38107 EAW72956 EAW72957 EAW72958 EAW72959 EAW72960 Q9UNH5 AA929031 AB209857 BAD93094 AF000367 AAB88277 AF064102 AAC16659 AF064103 AAC16660 AF122013 AAD49217 AK302310 BAG63648 AK310292 AK310657 BC038979 AAH38979 BC071578 BC093916 AAH93916 BC093918 AAH93918 BU609013 CB156695 DA461435 DA885382 DQ530256 ABF74568 XM_005271294 XP_005271351 XM_005271296 XP_005271353 XM_011542340 XP_011540642 XM_011542341 XP_011540643 XM_011542342 XP_011540644 XM_011542343 XP_011540645 XM_011542344 XP_011540646 XM_011542345 XP_011540647 XM_011542346 XP_011540648 NM_003672 NP_003663 NM_033312 NP_201569 NM_033313 NP_201570 |
| Function | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:9367992}. |
| Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle. |
| Top Pathways | Cell cycle |
Cdc14a phosphatase CRISPR/Cas9 KO Plasmid (h) - sc-411185 from Santa Cruz Biotechnology
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Cdc14a phosphatase HDR Plasmid (h) - sc-411185-HDR from Santa Cruz Biotechnology
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Cdc14a phosphatase Double Nickase Plasmid (h) - sc-411185-NIC from Santa Cruz Biotechnology
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Cdc14a phosphatase Double Nickase Plasmid (h2) - sc-411185-NIC-2 from Santa Cruz Biotechnology
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Cdc14a phosphatase CRISPR Activation Plasmid (h) - sc-411185-ACT from Santa Cruz Biotechnology
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Cdc14a phosphatase CRISPR Activation Plasmid (h2) - sc-411185-ACT-2 from Santa Cruz Biotechnology
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Cdc14a phosphatase Lentiviral Activation Particles (h) - sc-411185-LAC from Santa Cruz Biotechnology
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Cdc14a phosphatase Lentiviral Activation Particles (h2) - sc-411185-LAC-2 from Santa Cruz Biotechnology
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Cdc14a siRNA (h) - sc-37551 from Santa Cruz Biotechnology
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Cdc14a shRNA Plasmid (h) - sc-37551-SH from Santa Cruz Biotechnology
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Cdc14a shRNA (h) Lentiviral Particles - sc-37551-V from Santa Cruz Biotechnology
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Cdc14A RNAi - H00008556-R02 from Novus Biologicals
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MISSION® esiRNA - EHU090221 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0050 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0049 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0925 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0051 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0924 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2170 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2170 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12820 from Sigma-Aldrich
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CDC14A siRNA (Human) - CRH5625 from Cohesion Biosciences
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Cdc14A RNAi - H00008556-R01 from Novus Biologicals
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Cdc14A RNAi - H00008556-R03 from Novus Biologicals
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CDC14A - MBS8228662 from MyBioSource
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