| Gene Symbol |
ZFYVE21
|
| Entrez Gene |
79038
|
| Alt Symbol |
ZF21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 21
|
| Other Description |
FYVE domain containing 21|zinc finger FYVE domain-containing protein 21
|
| Swissprots |
Q96LT1 A8K3A4 Q86T05 Q9BQ24
|
| Accessions |
EAW81843 EAW81844 Q9BQ24 AK001921 AK057816 BAB71589 AK124507 AK226142 AK290519 BAF83208 AY395756 AAR14313 AY596776 AAT02353 BC001130 AAH01130 BC005999 AAH05999 BX248261 CAD62589 CA311020 CX786145 NM_001198953 NP_001185882 NM_024071 NP_076976
|
| Function |
Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression. {ECO:0000269|PubMed:20439989, ECO:0000269|PubMed:21768110}.
|
| Subcellular Location |
Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.
|
![Western Blot: ZFYVE21 Overexpression Lysate (Adult Normal) [NBL1-18027] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZFYVE21.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5770_ZFYVE21%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-18027-img0002.jpg)