Gene Symbol | ZFYVE21 |
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Entrez Gene | 79038 |
Alt Symbol | ZF21 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger, FYVE domain containing 21 |
Other Description | FYVE domain containing 21|zinc finger FYVE domain-containing protein 21 |
Swissprots | Q96LT1 A8K3A4 Q86T05 Q9BQ24 |
Accessions | EAW81843 EAW81844 Q9BQ24 AK001921 AK057816 BAB71589 AK124507 AK226142 AK290519 BAF83208 AY395756 AAR14313 AY596776 AAT02353 BC001130 AAH01130 BC005999 AAH05999 BX248261 CAD62589 CA311020 CX786145 NM_001198953 NP_001185882 NM_024071 NP_076976 |
Function | Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression. {ECO:0000269|PubMed:20439989, ECO:0000269|PubMed:21768110}. |
Subcellular Location | Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker. |
ZFYVE21 CRISPR/Cas9 KO Plasmid (h) - sc-413119 from Santa Cruz Biotechnology
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ZFYVE21 HDR Plasmid (h) - sc-413119-HDR from Santa Cruz Biotechnology
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ZFYVE21 Double Nickase Plasmid (h) - sc-413119-NIC from Santa Cruz Biotechnology
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ZFYVE21 Double Nickase Plasmid (h2) - sc-413119-NIC-2 from Santa Cruz Biotechnology
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ZFYVE21 CRISPR Activation Plasmid (h) - sc-413119-ACT from Santa Cruz Biotechnology
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ZFYVE21 CRISPR Activation Plasmid (h2) - sc-413119-ACT-2 from Santa Cruz Biotechnology
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ZFYVE21 Lentiviral Activation Particles (h) - sc-413119-LAC from Santa Cruz Biotechnology
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ZFYVE21 Lentiviral Activation Particles (h2) - sc-413119-LAC-2 from Santa Cruz Biotechnology
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ZFYVE21 siRNA (h) - sc-92444 from Santa Cruz Biotechnology
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ZFYVE21 shRNA Plasmid (h) - sc-92444-SH from Santa Cruz Biotechnology
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ZFYVE21 shRNA (h) Lentiviral Particles - sc-92444-V from Santa Cruz Biotechnology
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ZFYVE21 RNAi - H00079038-R01 from Novus Biologicals
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MISSION® esiRNA - EHU059951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23206 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23206 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05550 from Sigma-Aldrich
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ZFYVE21 siRNA (Human) - CRJ2273 from Cohesion Biosciences
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ZFYVE21 - MBS8209248 from MyBioSource
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shRNA set against Human ZFYVE21 (NM_024071.3) - SHH452492 from Creative biogene
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ZFYVE21 shRNA Plasmid (Human) - CHJ2273 from Cohesion Biosciences
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ZFYVE21 miRNA 3'UTR clone - MiUTR3H-12928 from Creative biogene
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