| Gene Symbol |
DHCR7
|
| Entrez Gene |
1717
|
| Alt Symbol |
SLOS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
7-dehydrocholesterol reductase
|
| Other Description |
7-DHC reductase|delta-7-dehydrocholesterol reductase|putative sterol reductase SR-2|sterol delta-7-reductase
|
| Swissprots |
O60492 O60717 Q9UBM7 B2R6Z2
|
| Accessions |
AAD24762 AAF06726 EAW74788 EAW74789 EAW74790 EAW74791 Q9UBM7 AF034544 AAC05086 AF062481 AAC18345 AF067127 AAD02816 AF096305 AAD09766 AI888720 AK289497 BAF82186 AK303881 BAG64817 AK309625 AK312775 BAG35639 BC000054 AAH00054 BU848891 DA502590 DQ891827 ABM82753 DQ895014 ABM85940 KJ534821 AHW56461 KJ534963 AHW56603 KJ534997 AHW56637 XM_011544777 XP_011543079 NM_001163817 NP_001157289 NM_001360 NP_001351
|
| Function |
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000269|PubMed:9878250}.
|
| Tissue Specificity |
Most abundant in adrenal gland, liver, testis, and brain. {ECO:0000269|PubMed:9878250}.
|
| Top Pathways |
Steroid biosynthesis
|
![Western Blot: DHCR7 Overexpression Lysate (Adult Normal) [NBL1-09858] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DHCR7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3525_DHCR7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09858-img0002.jpg)