DHCR7

Gene Symbol DHCR7
Entrez Gene 1717
Alt Symbol SLOS
Species Human
Gene Type protein-coding
Description 7-dehydrocholesterol reductase
Other Description 7-DHC reductase|delta-7-dehydrocholesterol reductase|putative sterol reductase SR-2|sterol delta-7-reductase
Swissprots O60492 O60717 Q9UBM7 B2R6Z2
Accessions AAD24762 AAF06726 EAW74788 EAW74789 EAW74790 EAW74791 Q9UBM7 AF034544 AAC05086 AF062481 AAC18345 AF067127 AAD02816 AF096305 AAD09766 AI888720 AK289497 BAF82186 AK303881 BAG64817 AK309625 AK312775 BAG35639 BC000054 AAH00054 BU848891 DA502590 DQ891827 ABM82753 DQ895014 ABM85940 KJ534821 AHW56461 KJ534963 AHW56603 KJ534997 AHW56637 XM_011544777 XP_011543079 NM_001163817 NP_001157289 NM_001360 NP_001351
Function Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000269|PubMed:9878250}.
Tissue Specificity Most abundant in adrenal gland, liver, testis, and brain. {ECO:0000269|PubMed:9878250}.
Top Pathways Steroid biosynthesis

DHCR7 (N-12) - sc-48481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DHCR7 (H-155) - sc-134500 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 antibody - ab103296 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab103296 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab103296, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-DHCR7 Antibody (aa444-471, AP) - LS-C256068 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471, Biotin) - LS-C256070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471, Azide-free, HRP) - LS-C256071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471, APC) - LS-C256069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471, FITC) - LS-C256072 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody - LS-C310122 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471) - LS-C320825 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHCR7 Antibody (aa444-471, PE) - LS-C256073 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

DHCR7 Antibody - H00001717-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DHCR7 Antibody [H00001717-D01P] - Analysis of DHCR7 expression in rat brain.

DHCR7 Antibody - NBP1-80740 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: DHCR7 Antibody [NBP1-80740] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

DHCR7 Polyclonal Antibody - bs-5057R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human HL-60 cell lysates probed with Anti-DHCR7 Polyclonal Antibody, Unconjugated (bs-5057R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:10000 for 90 min at 37˚C.

Anti-DHCR7 antibody produced in rabbit - SAB1401114 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-DHCR7, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401114</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Specific band of ~54.49 kDa using HepG2 lysate.

Anti-DHCR7 antibody produced in rabbit - HPA044280 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DHCR7: <B>Cat. No. HPA044280</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Anti-DHCR7 (16-30) antibody produced in rabbit - D7570 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-DHCR7 (16-30), <B>Cat. No. D7570</B>: Immunofluorescence of HUVEC cells using Anti-DHCR7 (16-30), D7570 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-DHCR7 (351-364) antibody produced in rabbit - D7695 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-DHCR7 (351-364) : <B>Cat. No. D7695</B>: Immunofluorescence of HUVEC cells using DHCR7 (351-364) , Cat. No. D7695 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

DHCR7-Antibody-C-term - AP11452b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
DHCR7 Antibody (C-term) (Cat. #AP11452b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the DHCR7 antibody detected the DHCR7 protein (arrow).

Rabbit-Anti-DHCR7-antibody - AP50932 from Abgent, a WuXi AppTec company

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from HepG2 cell line, using Rabbit Anti-DHCR7 antibody(bs-5057R). bs-5057R was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysate at 20ug.

DHCR7 antibody - GTX51622 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

7-DHC reductase (C-term) antibody - AP51252PU-N from Acris Antibodies

Host Rabbit
Clonality Polyclonal
DHCR7 Antibody (C-term) (Cat. #AP51252PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DHCR7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

7-DHC reductase antibody - H00001717-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
DHCR7 MaxPab rabbit polyclonal antibody. Western Blot analysis of DHCR7 expression in mouse testis.

Rabbit Anti-Mouse DHCR7 (C-term) - 102-11101 from RayBiotech

Host Rabbit
DHCR7 Antibody (C-term) (Cat# 102-11101) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the DHCR7 antibody detected the DHCR7 protein (arrow).

DHCR7 antibody (C-term) - STJ41620 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB17942
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