Gene Symbol | SGCB |
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Entrez Gene | 6443 |
Alt Symbol | A3b, LGMD2E, SGC |
Species | Human |
Gene Type | protein-coding |
Description | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
Other Description | 43 kDa dystrophin-associated glycoprotein|43DAG|beta-SG|beta-sarcoglycan|beta-sarcoglycan(43kD dystrophin-associated glycoprotein)|limb girdle muscular dystrophy 2E (non-linked families) |
Swissprots | Q16585 B7Z635 O00661 |
Accessions | AAB46956 CAA70920 EAX05429 EAX05430 Q16585 AK094731 AK289892 BAF82581 AK299765 BAH13121 BC020709 AAH20709 BC048972 BT019433 AAV38240 CA449352 CN483961 CR456810 CAG33091 DQ893140 ABM84066 DQ896425 ABM87424 EU176433 ABW03884 U29586 AAB41291 U31116 AAA87034 XM_006714049 XP_006714112 XM_011534403 XP_011532705 XM_011534404 XP_011532706 NM_000232 NP_000223 |
Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Subcellular Location | Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
Tissue Specificity | Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
β-sarcoglycan (H-98) - sc-28279 from Santa Cruz Biotechnology
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β-sarcoglycan (A-17) - sc-14176 from Santa Cruz Biotechnology
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β-sarcoglycan (S-16) - sc-14177 from Santa Cruz Biotechnology
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β-sarcoglycan (RO-17) - sc-100956 from Santa Cruz Biotechnology
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Anti-beta Sarcoglycan antibody - ab55683 from Abcam
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Anti-beta Sarcoglycan antibody - ab135954 from Abcam
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Anti-beta Sarcoglycan antibody [ßSarc/5B1] - ab49717 from Abcam
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa290-306) - LS-C3075 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa32-47) - LS-C3076 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (clone bSarc1/5B1) - LS-C189584 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa87-136) - LS-C286278 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa180-229) - LS-C102084 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa91-140) - LS-C201470 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (clone 1E3) IHC-plus⢠- LS-B10055 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (Val136) - LS-C177578 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (aa1-319, Azide-free) - LS-C330647 from LifeSpan Bioscience
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Anti-SGCB / SGC / Sarcoglycan Beta Antibody (clone 1C10) IHC-plus⢠- LS-B4415 from LifeSpan Bioscience
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beta Sarcoglycan Antibody - NBP1-59751 from Novus Biologicals
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beta Sarcoglycan Antibody (1C10) - H00006443-M02 from Novus Biologicals
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beta Sarcoglycan Antibody (1E3.) - H00006443-M01 from Novus Biologicals
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beta Sarcoglycan Antibody - NBP1-90300 from Novus Biologicals
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beta Sarcoglycan Antibody - H00006443-A01 from Novus Biologicals
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SGCB/SGC Polyclonal Antibody - bs-1127R from Bioss
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SGCB/SGC Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-1127R-A350 from Bioss
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SGCB/SGC Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-1127R-A488 from Bioss
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