| Gene Symbol |
ZNRF3
|
| Entrez Gene |
84133
|
| Alt Symbol |
BK747E2.3, RNF203
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc and ring finger 3
|
| Other Description |
CTA-292E10.6|E3 ubiquitin-protein ligase ZNRF3|RING finger protein 203|novel C3HC4 type Zinc finger (ring finger)|zinc/RING finger protein 3
|
| Swissprots |
Q6NTF8 B3KU18 Q8WU18 Q9ULT6 Q6ICH1
|
| Accessions |
EAW59767 EAW59768 EAW59769 EAW59770 Q9ULT6 AB051436 BAB33319 AI244417 AK022809 AK025710 AK096397 BAG53280 BC009252 AAH09252 BC021570 AAH21570 BC042614 BC051344 BC069019 AAH69019 BC094857 AAH94857 BC167805 AAI67805 CR456397 CAG30283 CU012955 CAK54386 CU013243 CAK54685 HG512185 HG512186 HG512188 HG512189 XM_005261773 XP_005261830 XM_011530434 XP_011528736 XM_011530435 XP_011528737 XM_011530436 XP_011528738 XM_011530437 XP_011528739 XM_011530438 XP_011528740 XM_011530439 XP_011528741 XM_011530440 XP_011528742 XM_011530441 XP_011528743 NM_001206998 NP_001193927 NM_032173 NP_115549
|
| Function |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:22575959}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22575959}; Single-pass type I membrane protein {ECO:0000269|PubMed:22575959}.
|