Gene Symbol | KAT6B |
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Entrez Gene | 23522 |
Alt Symbol | GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf |
Species | Human |
Gene Type | protein-coding |
Description | K(lysine) acetyltransferase 6B |
Other Description | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4|MOZ-related factor|MYST histone acetyltransferase (monocytic leukemia) 4|MYST-4|histone acetyltransferase KAT6B|histone acetyltransferase MORF|histone acetyltransferase MOZ2|histone acetyltransferase MYST4|monocytic leukemia zinc finger protein-related factor |
Swissprots | Q9UKW2 Q8WYB5 Q9UKX0 Q8WU81 Q86Y05 O15087 Q9UKW3 |
Accessions | EAW54557 EAW54558 EAW54559 Q8WYB5 AA416904 AB002381 BAA20837 AF113514 AAF00095 AF119230 AAF00099 AF119231 AAF00100 AF217500 AAL56647 AK074816 AL832065 CAH10408 BC014143 AAH14143 BC021128 AAH21128 BC048199 AAH48199 BC150270 AAI50271 BC150618 AAI50619 DA488537 XM_005269664 XP_005269721 XM_011548776 XP_011547078 NM_001256468 NP_001243397 NM_001256469 NP_001243398 NM_012330 NP_036462 |
Function | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. {ECO:0000269|PubMed:10497217}. |
MORF CRISPR/Cas9 KO Plasmid (h) - sc-418605 from Santa Cruz Biotechnology
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MORF HDR Plasmid (h) - sc-418605-HDR from Santa Cruz Biotechnology
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MORF Double Nickase Plasmid (h) - sc-418605-NIC from Santa Cruz Biotechnology
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MORF Double Nickase Plasmid (h2) - sc-418605-NIC-2 from Santa Cruz Biotechnology
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MORF CRISPR Activation Plasmid (h) - sc-418605-ACT from Santa Cruz Biotechnology
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MORF CRISPR Activation Plasmid (h2) - sc-418605-ACT-2 from Santa Cruz Biotechnology
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MORF Lentiviral Activation Particles (h) - sc-418605-LAC from Santa Cruz Biotechnology
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MORF Lentiviral Activation Particles (h2) - sc-418605-LAC-2 from Santa Cruz Biotechnology
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MORF siRNA (h) - sc-37955 from Santa Cruz Biotechnology
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MORF shRNA Plasmid (h) - sc-37955-SH from Santa Cruz Biotechnology
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MORF shRNA (h) Lentiviral Particles - sc-37955-V from Santa Cruz Biotechnology
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KAT6B-MORF RNAi - H00023522-R01 from Novus Biologicals
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MISSION® esiRNA - EHU089261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14888 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14888 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10658 from Sigma-Aldrich
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KAT6B siRNA (Human) - CRH8328 from Cohesion Biosciences
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KAT6B, siRNA - MBS8241392 from MyBioSource
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shRNA set against Human KAT6B (NM_012330.3) - SHH322455 from Creative biogene
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Human KAT6B siRNA - orb268830 from Biorbyt
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KAT6B shRNA Plasmid (Human) - CHH8328 from Cohesion Biosciences
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KAT6B miRNA 3'UTR clone - MiUTR3H-08013 from Creative biogene
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