HTR4

Gene Symbol HTR4
Entrez Gene 3360
Alt Symbol 5-HT4, 5-HT4R
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Other Description 5-hydroxytryptamine receptor 4|cardiac 5-HT4 receptor
Swissprots Q96KH9 Q546Q1 Q96KI0 Q9UBT4 Q9UBM6 C4WYH4 Q9UE22 Q13639 Q9NY73 Q684M0 Q9UE23 Q9UQR6 Q9H199 Q712M9
Accessions CAB71316 EAW61799 EAW61800 EAW61801 EAW61802 EAW61803 EAW61804 Q13639 AJ011371 CAA09600 AJ131724 CAC20411 AJ131725 CAC79533 AJ131726 CAC79538 AJ278979 CAC22248 AJ278980 CAC22249 AJ278981 CAC22250 AJ278982 CAC22251 AJ519673 CAD58392 AJ633645 CAG17627 AK095223 AK308471 AM712912 CAN84676 BC074755 AAH74755 BC095497 AAH95497 DR000612 Y08756 CAA70002 Y09586 CAA70774 Y10437 CAA71462 Y12505 CAA73107 Y12506 CAA73108 Y12507 CAA73109 Y13584 CAA73911 Z48150 CAA88167 NM_000870 NP_000861 NM_001040169 NP_001035259 NM_001040172 NP_001035262 NM_001040173 NP_001035263 NM_001286410 NP_001273339 NM_199453 NP_955525 NR_104445 NM_001040174
Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.
Tissue Specificity Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. {ECO:0000269|PubMed:15118808}.
Top Pathways Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction

5-HTR4 (D8O5K) Rabbit mAb - 13690 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8O5K
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human 5-HTR4 (h5-HTR4-Myc/DDK; +), using 5-HTR4 (D8O5K) Rabbit mAb.

SR-4 (G-3) - sc-376158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SR-4 (G-3): sc-376158. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

SR-4 (C-18) - sc-32566 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-4 (H-129) - sc-28959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SR-4 (K-19) - sc-19155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-4 (N-16) - sc-19154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-4 (N-16): sc-19154. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

SR-4 (N-18) - sc-32564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-4 (N-18): sc-32564. Western blot analysis of SR-4 expression in U-87 MG whole cell lysate (A) and rat heart (B), rat brain (C) and mouse brain (D) tissue extracts.

Anti-5HT4 Receptor antibody - ab60359 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5HT4 Receptor antibody (ab60359)Lane 1 : 293 cells treated with insulin (0.01U/ml, 15 mins)Lane 2 : 293 cells treated with insulin (0.01U/ml, 15 mins) with blocking peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-5HT4 Receptor antibody - ab101910 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab101910 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab101910 at 1/1000 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-5HT4 Receptor antibody - ab87337 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5HT4 Receptor antibody (ab87337) at 2 µg/mlLane 1 : Caco 2 (Human colonic carcinoma cell line) Whole Cell Lysate Lane 2 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-5HT4 Receptor antibody - ab113004 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT4 Receptor antibody (ab113004) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

Anti-5HT4 Receptor antibody - ab124642 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab124642, at 10µg/ml, staining 5HT4 Receptor in Formalin-fixed, Paraffin-embedded Human adrenal tissue by Immunohistochemistry.

Anti-HTR4 / 5-HT4 Receptor Antibody (Biotin) - LS-C180891 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR4 / 5-HT4 Receptor Antibody (aa1-30) - LS-C165086 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HTR4 Antibody western blot of MDA-MB453(lane 1) cell line and mouse liver(lane 2) tissue lysates (35 ug/lane). The HTR4 antibody detected the HTR4 protein (arrow).

Anti-HTR4 / 5-HT4 Receptor Antibody (aa144-193) - LS-C112321 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HTR4 / 5-HT34 antibody LS-C112321 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-HTR4 / 5-HT4 Receptor Antibody (DY650) - LS-C180892 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR4 / 5-HT4 Receptor Antibody (aa141-190) - LS-C120546 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF7 cells, using HTR4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-HTR4 / 5-HT4 Receptor Antibody (aa21-70) - LS-C119371 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using 5-HT-4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-HTR4 / 5-HT4 Receptor Antibody (C-Terminus) IHC-plus™ - LS-B6136 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-5HT4 Receptor antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6136 concentration 5 ug/ml.

Anti-HTR4 / 5-HT4 Receptor Antibody (DY488) - LS-C180893 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR4 / 5-HT4 Receptor Antibody (Asn180) - LS-C177076 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SR-4 (N180) pAb in extracts from NIH-3T3 cells.

Anti-HTR4 / 5-HT4 Receptor Antibody (DY550) - LS-C180894 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR4 / 5-HT4 Receptor Antibody (C-Terminus) IHC-plus™ - LS-A656 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT4 Receptor antibody LS-A656 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR4 / 5-HT4 Receptor Antibody (C-Terminus) IHC-plus™ - LS-A657 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT4 Receptor antibody LS-A657 IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR4 / 5-HT4 Receptor Antibody (aa1-30, APC) - LS-C222796 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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