HTR4
| Gene Symbol | HTR4 |
|---|---|
| Entrez Gene | 3360 |
| Alt Symbol | 5-HT4, 5-HT4R |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled |
| Other Description | 5-hydroxytryptamine receptor 4|cardiac 5-HT4 receptor |
| Swissprots | Q96KH9 Q546Q1 Q96KI0 Q9UBT4 Q9UBM6 C4WYH4 Q9UE22 Q13639 Q9NY73 Q684M0 Q9UE23 Q9UQR6 Q9H199 Q712M9 |
| Accessions | CAB71316 EAW61799 EAW61800 EAW61801 EAW61802 EAW61803 EAW61804 Q13639 AJ011371 CAA09600 AJ131724 CAC20411 AJ131725 CAC79533 AJ131726 CAC79538 AJ278979 CAC22248 AJ278980 CAC22249 AJ278981 CAC22250 AJ278982 CAC22251 AJ519673 CAD58392 AJ633645 CAG17627 AK095223 AK308471 AM712912 CAN84676 BC074755 AAH74755 BC095497 AAH95497 DR000612 Y08756 CAA70002 Y09586 CAA70774 Y10437 CAA71462 Y12505 CAA73107 Y12506 CAA73108 Y12507 CAA73109 Y13584 CAA73911 Z48150 CAA88167 NM_000870 NP_000861 NM_001040169 NP_001035259 NM_001040172 NP_001035262 NM_001040173 NP_001035263 NM_001286410 NP_001273339 NM_199453 NP_955525 NR_104445 NM_001040174 |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}. |
| Tissue Specificity | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. {ECO:0000269|PubMed:15118808}. |
| Top Pathways | Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction |
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