| Gene Symbol |
NUDT11
|
| Entrez Gene |
55190
|
| Alt Symbol |
APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 11
|
| Other Description |
DIPP-3-beta|DIPP3-beta|diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta|diadenosine hexaphosphate hydrolase (AMP-forming)|diphosphoinositol polyphosphate phosphohydrolase 3, beta|diphosphoinositol polyphosphate phosphohydrolase 3-beta|hAps1|nucleoside diphosphate-linked moiety X motif 11|nudix motif 11
|
| Swissprots |
Q9NVN0 Q96G61
|
| Accessions |
EAW89906 Q96G61 AK001490 BAA91720 AM392606 CAL37484 BC009942 AAH09942 BX419815 NM_018159 NP_060629
|
| Function |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12121577}.
|
| Tissue Specificity |
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart. {ECO:0000269|PubMed:12105228, ECO:0000269|PubMed:12121577}.
|