| Gene Symbol |
CDK6
|
| Entrez Gene |
1021
|
| Alt Symbol |
MCPH12, PLSTIRE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 6
|
| Other Description |
cell division protein kinase 6|serine/threonine-protein kinase PLSTIRE
|
| Swissprots |
Q00534 A4D1G0
|
| Accessions |
AAM76970 EAL24146 EAW76827 EAW76828 EAW76829 Q00534 AA312213 AB073601 AI023175 AI367890 AI400582 AI738486 AI935072 AK000660 AK055922 AK123134 AK172791 AK313491 BAG36273 AV726767 AW665776 BC012914 BC027989 BC052264 AAH52264 BC063591 BC065026 BE893003 BG166127 BM542578 BM542629 BM542736 BM905472 BM978533 BQ048881 BQ213893 BQ231384 BQ773638 BU159055 X66365 CAA47008 XM_006715835 XP_006715898 XM_006715836 XP_006715899 XM_011515731 XP_011514033 NM_001145306 NP_001138778 NM_001259 NP_001250
|
| Function |
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents my
|
| Subcellular Location |
Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23918663}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250|UniProtKB:Q64261, ECO:0000269|PubMed:23918663}.
|
| Tissue Specificity |
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. {ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:8114739}.
|
| Top Pathways |
Cell cycle, Glioma, Pancreatic cancer, Measles, Non-small cell lung cancer
|