CREBZF

Gene Symbol CREBZF
Entrez Gene 58487
Alt Symbol SMILE, ZF
Species Human
Gene Type protein-coding
Description CREB/ATF bZIP transcription factor
Other Description HCF-binding transcription factor Zhangfei|SHP-interacting leucine zipper protein|Zhangfei|host cell factor-binding transcription factor Zhangfei
Swissprots Q52LT3 Q9NS37 Q0P5U9 B2R8Q9
Accessions EAW75103 Q9NS37 AF039942 AAD28325 AK313471 BAG36256 AL045702 AL110236 BC060807 AAH60807 BC093796 AAH93796 BC093798 AAH93798 BF063403 BM461709 BQ720558 CA843387 CN275782 DB212122 DB546868 DQ128105 AAZ42189 EU446879 ABZ92408 XM_006718642 XP_006718705 XM_011545195 XP_011543497 NM_021212 NM_001039618 NP_001034707 NR_028024 NR_028025 NR_028026 NR_028027
Function Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
Tissue Specificity In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver. {ECO:0000269|PubMed:10871379}.

Zhangfei (C-15) - sc-49328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Zhangfei (D-15) - sc-49329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zhangfei (D-15): sc-49329. Western blot analysis of Zhangfei expression in non-transfected: sc-117752 (A) and human Zhangfei transfected: sc-369904 (B) 293T whole cell lysates.

Zhangfei (T-20) - sc-49330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zhangfei (T-20): sc-49330. Western blot analysis of Zhangfei expression in MIA PaCa-2 (A) and COLO205 (B) whole cell lysates.

Anti-Zhangfei antibody - ab28700 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Zhangfei antibody (ab28700) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 3 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 4 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 5 : 293T Embryonic Kidney cell line (Human) Whole Cell Lysate Lane 6 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 7 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 8 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 9 : PC3 (Human prostate cancer cell line) Whole Cell Lysate (ab3954)Lane 10 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutionPerformed under reducing conditions.

Anti-Zhangfei antibody - ab107617 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Zhangfei antibody (ab107617) at 1 µg/ml + K562 cell lysate at 15 µg

Anti-Zhangfei antibody - ab85468 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Zhangfei antibody (ab85468) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Zhangfei antibody - ab136037 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Zhangfei antibody (ab136037) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-CREBZF / Zhangfei Antibody (C-Terminus) - LS-C101589 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CREBZF antibody LS-C101589 Western blot of Fetal Muscle lysate.

Anti-CREBZF / Zhangfei Antibody (C-Terminus) - LS-C80141 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CCRF-CEM cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-CREBZF / Zhangfei Antibody (aa215-264) - LS-C108007 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CREBZF antibody LS-C108007 Western blot of Fetal Stomach lysate.

Anti-CREBZF / Zhangfei Antibody (aa279-309, APC) - LS-C255418 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309, AP) - LS-C255417 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa221-270) - LS-C119281 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using CREBZF Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CREBZF / Zhangfei Antibody (aa279-309, Biotin) - LS-C255419 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309, PE) - LS-C255422 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309, Azide-free, HRP) - LS-C255421 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309, FITC) - LS-C255420 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa112-161) - LS-C291833 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309) - LS-C320589 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREBZF / Zhangfei Antibody (aa279-309) - LS-C159404 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CREBZF Antibody western blot of A549 cell line lysates (35 ug/lane). The CREBZF antibody detected the CREBZF protein (arrow).

Anti-CREBZF / Zhangfei Antibody (N-Terminus) - LS-C144333 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunocytochemistry of ZHANGFEI in K562 cells with ZHANGFEI antibody at 10 ug/ml.

Zhangfei Antibody - NBP1-76539 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Zhangfei Antibody - NBP2-13874 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Zhangfei Antibody [NBP2-13874] - Staining of human cerebellum shows moderate nuclear and cytoplasmic positivity in Purkinje cells.

Zhangfei Antibody - NBP2-20954 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Zhangfei Antibody [NBP2-20954] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 10% SDS PAGE gel, diluted at 1:1000.

Anti-CREBZF, C-Terminal antibody produced in rabbit - SAB4502556 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CREBZF, C-Terminal: <B>Cat. No. SAB4502556</B>: Immunofluorescence of HepG2 cells using Anti-CREBZF, C-Terminal antibody. Cells on the left were treated with the Anti-CREBZF, C-Terminal antibody. Cells on the right (negative control) were treated with both Anti-CREBZF, C-Terminal antibody and the synthesized immunogen peptide.
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