| Gene Symbol | CREBZF |
|---|---|
| Entrez Gene | 58487 |
| Alt Symbol | SMILE, ZF |
| Species | Human |
| Gene Type | protein-coding |
| Description | CREB/ATF bZIP transcription factor |
| Other Description | HCF-binding transcription factor Zhangfei|SHP-interacting leucine zipper protein|Zhangfei|host cell factor-binding transcription factor Zhangfei |
| Swissprots | Q52LT3 Q9NS37 Q0P5U9 B2R8Q9 |
| Accessions | EAW75103 Q9NS37 AF039942 AAD28325 AK313471 BAG36256 AL045702 AL110236 BC060807 AAH60807 BC093796 AAH93796 BC093798 AAH93798 BF063403 BM461709 BQ720558 CA843387 CN275782 DB212122 DB546868 DQ128105 AAZ42189 EU446879 ABZ92408 XM_006718642 XP_006718705 XM_011545195 XP_011543497 NM_021212 NM_001039618 NP_001034707 NR_028024 NR_028025 NR_028026 NR_028027 |
| Function | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1. |
| Tissue Specificity | In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver. {ECO:0000269|PubMed:10871379}. |