PPP1CB

Gene Symbol PPP1CB
Entrez Gene 5500
Alt Symbol HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD
Species Human
Gene Type protein-coding
Description protein phosphatase 1, catalytic subunit, beta isozyme
Other Description epididymis secretory sperm binding protein Li 80p|protein phosphatase 1, catalytic subunit, beta isoform|protein phosphatase 1, catalytic subunit, delta isoform|protein phosphatase 1-beta|protein phosphatase 1-delta|serine/threonine protein phosphatase PP1-beta catalytic subunit|serine/threonine-protein phosphatase PP1-beta catalytic subunit
Swissprots B2R5V4 P37140 Q6FG45 Q5U087 P62140 D6W565
Accessions AAA85093 AAY24124 EAX00527 EAX00528 EAX00529 EAX00530 P62140 AF092905 AAF01137 AI147919 AK295957 BAG58737 AK303682 BAG64675 AK312329 BAG35251 AK316532 BAH14903 AM392772 CAL37650 BC002697 AAH02697 BC012045 AAH12045 BE047402 BI551898 BM835970 BQ933435 BT019744 AAV38549 BU740022 BX477003 BX647295 BX647970 CB111140 CD656807 CD722576 CR542263 CAG47059 CR542285 CAG47080 EU668339 ACF94492 X80910 CAA56870 NM_002709 NP_002700 NM_206876 NP_996759 NM_206877
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB), Human, ELISA Kit - CSB-EL018504HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB), Human, ELISA Kit - E01S0343 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Serine/threonine protein phosphatase PP1 beta catalytic subunit (PPP1CB), ELISA Kit - MBS7223162 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

protein phosphatase 1, catalytic subunit, beta isoform, ELISA Kit - MBS943292 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human PPP1CB is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 15.6 pg/ml -1000 pg/ml.

Human Serine/threonine-protein phosphatase PP1-beta catalytic subunit(PPP1CB) ELISA kit - CSB-EL018504HU from Cusabio

Category ELISA Kit
Sensitivity 3.9pg/ml
Range 15.6 pg/ml-1000 pg/ml

Human PPP1CB ELISA Kit - E031705 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human PPP1CB is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

anti-PPP1CB antibody - ARG57470 from Arigo Biolaboratories

Category ELISA Kit

PPP1CB ELISA Kit (Human) (OKCA01513) - OKCA01513 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 3.9 pg/mL
Range 15.6 - 1,000 pg/mL

Human PPP1CB ELISA Kit - orb407105 from Biorbyt

Category ELISA Kit
Sensitivity 3.9pg/ml
Range 15.6 pg/ml-1000 pg/ml
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